Salidroside improves angiogenesis-osteogenesis coupling by regulating the HIF-1&#945;/VEGF signalling pathway in the bone environment.

Guo, Qiaoyun; Yang, Jing; Chen, Yumeng; Jin, Xin; Li, Zongmin; Wen, Xiaochang; Xia, Qun; Wang, Yue

Salidroside improves angiogenesis-osteogenesis coupling by regulating the HIF-1α/VEGF signalling pathway in the bone environment.

Guo, Qiaoyun; Yang, Jing; Chen, Yumeng; Jin, Xin; Li, Zongmin; Wen, Xiaochang; Xia, Qun; Wang, Yue.

Afiliación

Guo Q; School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China; Department of Pathogenic Biology and Immunology, Logistics College of Chinese People's Armed Police Forces, Tianjin, 300309, China.
Yang J; Department of Pathogenic Biology and Immunology, Logistics College of Chinese People's Armed Police Forces, Tianjin, 300309, China.
Chen Y; College of Pharmacy, Tianjin Medical University, Tianjin, 300070, China.
Jin X; Department of Pharmacology, Logistics College of Chinese People's Armed Police Forces, Tianjin, 300309, China.
Li Z; Department of Pathogenic Biology and Immunology, Logistics College of Chinese People's Armed Police Forces, Tianjin, 300309, China; Department of Clinical Laboratory, Shanghai Crops Hospital of Chinese People's Armed Police Forces, Shanghai, China.
Wen X; Department of Pathogenic Biology and Immunology, Logistics College of Chinese People's Armed Police Forces, Tianjin, 300309, China.
Xia Q; Department of Orthopaedics, Characteristic Medical Center of Chinese People's Armed Police Force, Tianjin, 300162, China. Electronic address: xiaqun6@163.com.
Wang Y; School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China; Department of Pathogenic Biology and Immunology, Logistics College of Chinese People's Armed Police Forces, Tianjin, 300309, China. Electronic address: wangyue6808@126.com.

Eur J Pharmacol ; 884: 173394, 2020 Oct 05.

Article en En | MEDLINE | ID: mdl-32730833

Asunto(s)

Glucósidos/farmacología; Células Endoteliales de la Vena Umbilical Humana/efectos de los fármacos; Subunidad alfa del Factor 1 Inducible por Hipoxia/metabolismo; Huesos Metatarsianos/irrigación sanguínea; Neovascularización Fisiológica/efectos de los fármacos; Osteoblastos/efectos de los fármacos; Osteogénesis/efectos de los fármacos; Comunicación Paracrina; Fenoles/farmacología; Factor A de Crecimiento Endotelial Vascular/metabolismo; Animales; Línea Celular Tumoral; Movimiento Celular/efectos de los fármacos; Proliferación Celular/efectos de los fármacos; Microambiente Celular; Medios de Cultivo Condicionados/metabolismo; Femenino; Curación de Fractura/efectos de los fármacos; Células Endoteliales de la Vena Umbilical Humana/metabolismo; Humanos; Subunidad alfa del Factor 1 Inducible por Hipoxia/genética; Ratones Endogámicos BALB C; Osteoblastos/metabolismo; Embarazo; Transducción de Señal; Factor A de Crecimiento Endotelial Vascular/genética

Palabras clave

Angiogenesis; Endothelial cells; Hypoxia-inducible factor-1α (HIF-1α); Osteogenesis; Salidroside; Vascular endothelial growth factor (VEGF)

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Osteoblastos / Osteogénesis / Fenoles / Huesos Metatarsianos / Neovascularización Fisiológica / Comunicación Paracrina / Factor A de Crecimiento Endotelial Vascular / Subunidad alfa del Factor 1 Inducible por Hipoxia / Células Endoteliales de la Vena Umbilical Humana / Glucósidos Límite: Animals / Female / Humans / Pregnancy Idioma: En Revista: Eur J Pharmacol Año: 2020 Tipo del documento: Article País de afiliación: China

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