Inhibition of hepatocyte growth factor/c-Met signalling abrogates joint destruction by suppressing monocyte migration in rheumatoid arthritis.

Hosonuma, Masahiro; Sakai, Nobuhiro; Furuya, Hidekazu; Kurotaki, Yutaro; Sato, Yurie; Handa, Kazuaki; Dodo, Yusuke; Ishikawa, Koji; Tsubokura, Yumi; Negishi-Koga, Takako; Tsuji, Mayumi; Kasama, Tsuyoshi; Kiuchi, Yuji; Takami, Masamichi; Isozaki, Takeo

Hosonuma, Masahiro; Sakai, Nobuhiro; Furuya, Hidekazu; Kurotaki, Yutaro; Sato, Yurie; Handa, Kazuaki; Dodo, Yusuke; Ishikawa, Koji; Tsubokura, Yumi; Negishi-Koga, Takako; Tsuji, Mayumi; Kasama, Tsuyoshi; Kiuchi, Yuji; Takami, Masamichi; Isozaki, Takeo.

Afiliación

Hosonuma M; Division of Rheumatology, Department of Medicine, Showa University School of Medicine, Shinagawa.
Sakai N; Division of Medical Pharmacology, Department of Pharmacology, Showa University School of Medicine, Shinagawa.
Furuya H; Department of Pharmacology, Showa University School of Dentistry, Shinagawa.
Kurotaki Y; Parmacological Research Center, Showa University, Shinagawa.
Sato Y; Department of Pharmacology, Showa University School of Dentistry, Shinagawa.
Handa K; Parmacological Research Center, Showa University, Shinagawa.
Dodo Y; Division of Rheumatology, Department of Medicine, Showa University School of Medicine, Shinagawa.
Ishikawa K; Department of Pharmacology, Showa University School of Dentistry, Shinagawa.
Tsubokura Y; Parmacological Research Center, Showa University, Shinagawa.
Negishi-Koga T; Division of Community-Based Comprehensive Dentistry, Department of Special Needs Dentistry, School of Dentistry, Showa University, Ota.
Tsuji M; Department of Pharmacology, Showa University School of Dentistry, Shinagawa.
Kasama T; Parmacological Research Center, Showa University, Shinagawa.
Kiuchi Y; Division of Dentistry for Persons with Disabilities, School of Dentistry, Showa University, Ota.
Takami M; Division of Medical Pharmacology, Department of Pharmacology, Showa University School of Medicine, Shinagawa.
Isozaki T; Department of Pharmacology, Showa University School of Dentistry, Shinagawa.

Rheumatology (Oxford) ; 60(1): 408-419, 2021 01 05.

Article en En | MEDLINE | ID: mdl-32770199

Asunto(s)

Artritis Reumatoide/metabolismo; Movimiento Celular/efectos de los fármacos; Factor de Crecimiento de Hepatocito/metabolismo; Monocitos/metabolismo; Proteínas Proto-Oncogénicas c-met/metabolismo; Transducción de Señal/efectos de los fármacos; Adulto; Anciano; Anciano de 80 o más Años; Animales; Artritis Reumatoide/sangre; Línea Celular Tumoral; Femenino; Factor de Crecimiento de Hepatocito/sangre; Humanos; Inflamación/metabolismo; Masculino; Ratones; Persona de Mediana Edad; Monocitos/efectos de los fármacos; Osteoartritis/sangre; Osteoartritis/metabolismo; Proteínas Proto-Oncogénicas c-met/sangre; Membrana Sinovial/metabolismo

Palabras clave

c-Met; chemokines; hepatocyte growth factor; rheumatoid arthritis

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Artritis Reumatoide / Monocitos / Transducción de Señal / Movimiento Celular / Factor de Crecimiento de Hepatocito / Proteínas Proto-Oncogénicas c-met Tipo de estudio: Prognostic_studies Límite: Adult / Aged / Aged80 / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Rheumatology (Oxford) Asunto de la revista: REUMATOLOGIA Año: 2021 Tipo del documento: Article

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