IL-10-1082G>A polymorphism, use of opioids and age affect the course of acute pancreatitis.
Eur J Gastroenterol Hepatol
; 32(2): 178-185, 2021 02 01.
Article
en En
| MEDLINE
| ID: mdl-32804849
ABSTRACT
PURPOSE:
We aimed to determine the association of two of the most important functional polymorphisms of IL-8 and IL-10 with the clinical course and outcome of acute pancreatitis.METHOD:
Ninety-three patients with acute pancreatitis were genotyped for IL-8-251T>A and IL-10-1082G>A using PCR-RFLP. The severity of the disease was determined based on the Atlanta Classification system.RESULTS:
In patients treated with opioids, the odds for severe form of acute pancreatitis, its complications, and death were increased. Advanced age was associated with higher odds of organ/multiple organ failure and other systemic complications. Multivariate logistic regression analyses confirmed the observed effect of age and use of opioids, and revealed higher odds for the development of severe form of acute pancreatitis [P = 0.017, odds ratio (OR) 4.324, 95% confidence interval (CI) 1.305-14.323], its complications in general (P = 0.011, OR 4.936, 95% CI 1.442-16.897), pancreatic necrosis (P = 0.032, OR 3.922, 95% CI 1.122-13.707) and systemic inflammatory response syndrome (P = 0.037, OR 3.838, 95% CI 1.085-13.583) in the absence of IL-10-1082G>A variant allele. The effect of IL-8 -251T>A on acute pancreatitis severity or mortality was not detected.CONCLUSION:
Our study suggests the IL-10 -1082A allele as a protective factor in acute pancreatitis. Opioid analgesics treatment in acute pancreatitis is associated with severity, complications and mortality, while advanced age increases the risk of systemic complications.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Pancreatitis
/
Analgésicos Opioides
Tipo de estudio:
Diagnostic_studies
Límite:
Humans
Idioma:
En
Revista:
Eur J Gastroenterol Hepatol
Asunto de la revista:
GASTROENTEROLOGIA
Año:
2021
Tipo del documento:
Article