Exosite binding drives substrate affinity for the activation of coagulation factor X by the intrinsic Xase complex.

Basavaraj, Manjunath Goolyam; Krishnaswamy, Sriram

Basavaraj, Manjunath Goolyam; Krishnaswamy, Sriram.

Afiliación

Basavaraj MG; Research Institute, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Krishnaswamy S; Research Institute, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA; Department of Pediatrics, University of Pennsylvania, Philadelphia, Pennsylvania, USA. Electronic address: skrishna@pennmedicine.upenn.edu.

J Biol Chem ; 295(45): 15198-15207, 2020 11 06.

Article en En | MEDLINE | ID: mdl-32859749

Asunto(s)

Factor IXa/metabolismo; Factor VIIIa/metabolismo; Factor X/metabolismo; Sitios de Unión; Humanos; Cinética; Proteínas Recombinantes/metabolismo

Palabras clave

coagulation factor; enzyme kinetics; enzyme mechanism; exosites; factor IXa; factor VIII (FVIII); factor X; factor X activation; intrinsic Xase; serine protease; serine proteinase

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Factor X / Factor VIIIa / Factor IXa Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Biol Chem Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos

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