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Impact of 2018 ASCO/CAP guidelines on HER-2 reporting categories of IHC and reflex FISH in breast cancer.
Pasricha, Sunil; Menon, Vidya; Gupta, Gurudutt; Kamboj, Meenakshi; Sharma, Anila; Durga, Garima; Tripathi, Rupal; Batra, Ullas; Jajodia, Ankush; Koyyala, Venkata Pradeep Babu; Agrawal, Chaturbhuj; Doval, Dinesh C; Mehta, Anurag.
Afiliación
  • Pasricha S; Department of Pathology, Rajiv Gandhi Cancer Institute and Research Centre, Delhi, India.
  • Menon V; Department of Pathology, Rajiv Gandhi Cancer Institute and Research Centre, Delhi, India.
  • Gupta G; Department of Pathology, Rajiv Gandhi Cancer Institute and Research Centre, Delhi, India.
  • Kamboj M; Department of Pathology, Rajiv Gandhi Cancer Institute and Research Centre, Delhi, India.
  • Sharma A; Department of Pathology, Rajiv Gandhi Cancer Institute and Research Centre, Delhi, India.
  • Durga G; Department of Pathology, Rajiv Gandhi Cancer Institute and Research Centre, Delhi, India.
  • Tripathi R; Department of Research, Rajiv Gandhi Cancer Institute and Research Centre, Delhi, India.
  • Batra U; Department of Medical Oncology, Rajiv Gandhi Cancer Institute and Research Centre, Delhi, India.
  • Jajodia A; Department of Radiodiagnosis, Rajiv Gandhi Cancer Institute and Research Centre, Delhi, India.
  • Koyyala VPB; Department of Medical Oncology, Rajiv Gandhi Cancer Institute and Research Centre, Delhi, India.
  • Agrawal C; Department of Medical Oncology, Rajiv Gandhi Cancer Institute and Research Centre, Delhi, India.
  • Doval DC; Department of Medical Oncology, Rajiv Gandhi Cancer Institute and Research Centre, Delhi, India.
  • Mehta A; Department of Pathology, Rajiv Gandhi Cancer Institute and Research Centre, Delhi, India.
Breast J ; 26(11): 2213-2216, 2020 11.
Article en En | MEDLINE | ID: mdl-32864808
ABSTRACT
Human epidermal growth factor receptor 2 (HER-2) is an established prognostic and predictive biomarker for breast cancer. To ensure accuracy and uniformity for HER-2 testing, ASCO/CAP published guidelines in 2007 which were updated in 2013 and recently in 2018. In this first study from Indian Oncology center, we evaluated the impact of 2018 ASCO/CAP guidelines. We found a substantial decrease in equivocal IHC cases (P-value < .00001). On reclassification, a total of 5.6% cases from equivocal and positive categories (2013 guidelines) shifted to the negative FISH result category (P-value < .0001), with adoption of 2018 guidelines and eliminated the double equivocal cases.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias de la Mama Tipo de estudio: Guideline / Prognostic_studies Límite: Female / Humans Idioma: En Revista: Breast J Asunto de la revista: NEOPLASIAS Año: 2020 Tipo del documento: Article País de afiliación: India
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias de la Mama Tipo de estudio: Guideline / Prognostic_studies Límite: Female / Humans Idioma: En Revista: Breast J Asunto de la revista: NEOPLASIAS Año: 2020 Tipo del documento: Article País de afiliación: India