<i>ADAMTS9-AS2</i> and <i>CADM2</i> expression and association with the prognosis in esophageal squamous cell carcinoma.

Shen, Fang-Fang; Zhang, Fan; Yang, Hai-Jun; Li, Jun-Kuo; Su, Jing-Fen; Yu, Pan-Ting; Zhou, Fu-You; Che, Guo-Wei

ADAMTS9-AS2 and CADM2 expression and association with the prognosis in esophageal squamous cell carcinoma.

Shen, Fang-Fang; Zhang, Fan; Yang, Hai-Jun; Li, Jun-Kuo; Su, Jing-Fen; Yu, Pan-Ting; Zhou, Fu-You; Che, Guo-Wei.

Afiliación

Shen FF; Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Zhang F; The Key Laboratory for Tumor Translational Medicine, The Third Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan, China.
Yang HJ; The Key Laboratory for Tumor Translational Medicine, The Third Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan, China.
Li JK; Anyang key Laboratory for Esophageal Cancer Research, Anyang Tumor Hospital, Anyang, Henan, China.
Su JF; Anyang key Laboratory for Esophageal Cancer Research, Anyang Tumor Hospital, Anyang, Henan, China.
Yu PT; Anyang key Laboratory for Esophageal Cancer Research, Anyang Tumor Hospital, Anyang, Henan, China.
Zhou FY; The Key Laboratory for Tumor Translational Medicine, The Third Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan, China.
Che GW; Anyang key Laboratory for Esophageal Cancer Research, Anyang Tumor Hospital, Anyang, Henan, China.

Biomark Med ; 14(15): 1415-1426, 2020 10.

Article en En | MEDLINE | ID: mdl-32892630

ABSTRACT

ABSTRACT

Background:

We investigated whether ADAMTS9-AS2 and CADM2 were related to esophageal squamous cell carcinoma (ESCC).

Methodology:

ESCC microarray datasets and reverse transcriptase qualitative PCR were used to analyze ADAMTS9-AS2 and CADM2 expression.

Results:

The GSE120356 and GSE33810 datasets identified ADAMTS9-AS2 and CADM2 as the candidates and ADAMTS9-AS2 and CADM2 expression was downregulated in ESCC. ADAMTS9-AS2 and CADM2 were positively correlated with ESCC. ADAMTS9-AS2 and CADM2 expression could discriminate ESCC from normal tissue. Five-year overall survival was shorter in underexpressed ADAMTS9-AS2 patients, and CADM2 expression level was related to 5-year overall survival. ADAMTS9-AS2 and CADM2 expression were independent prognosis indicators in ESCC patients.

Conclusion:

Our findings shed new light on the clinical significance of ADAMTS9-AS2 and CADM2 in ESCC carcinogenesis.

Asunto(s)

Moléculas de Adhesión Celular/genética; Carcinoma de Células Escamosas de Esófago/genética; ARN Largo no Codificante/genética; Proteína ADAMTS9/genética; Proteína ADAMTS9/metabolismo; Adulto; Anciano; Anciano de 80 o más Años; Apoptosis/genética; Moléculas de Adhesión Celular/metabolismo; Línea Celular Tumoral; Proliferación Celular/genética; China; Bases de Datos Genéticas; Neoplasias Esofágicas/patología; Carcinoma de Células Escamosas de Esófago/metabolismo; Femenino; Expresión Génica/genética; Regulación Neoplásica de la Expresión Génica/genética; Neoplasias de Cabeza y Cuello/genética; Humanos; Masculino; MicroARNs/genética; Persona de Mediana Edad; Pronóstico; ARN Largo no Codificante/metabolismo; Transducción de Señal/genética; Carcinoma de Células Escamosas de Cabeza y Cuello/genética; Transcriptoma/genética

Palabras clave

ADAMTS9-AS2; CADM2; esophageal squamous cell carcinoma; overall survival; prognosis

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Moléculas de Adhesión Celular / ARN Largo no Codificante / Carcinoma de Células Escamosas de Esófago Tipo de estudio: Prognostic_studies / Qualitative_research / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Biomark Med Asunto de la revista: BIOQUIMICA / MEDICINA Año: 2020 Tipo del documento: Article País de afiliación: China

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