Single Nucleotide Resolution Analysis Reveals Pervasive, Long-Lasting DNA Methylation Changes by Developmental Exposure to a Mitochondrial Toxicant.

Lozoya, Oswaldo A; Xu, Fuhua; Grenet, Dagoberto; Wang, Tianyuan; Grimm, Sara A; Godfrey, Veronica; Waidyanatha, Suramya; Woychik, Richard P; Santos, Janine H

Lozoya, Oswaldo A; Xu, Fuhua; Grenet, Dagoberto; Wang, Tianyuan; Grimm, Sara A; Godfrey, Veronica; Waidyanatha, Suramya; Woychik, Richard P; Santos, Janine H.

Afiliación

Lozoya OA; Genome Integrity and Structural Biology Laboratory, National Institutes of Health, Research Triangle Park, NC 27709, USA.
Xu F; Genome Integrity and Structural Biology Laboratory, National Institutes of Health, Research Triangle Park, NC 27709, USA.
Grenet D; Genome Integrity and Structural Biology Laboratory, National Institutes of Health, Research Triangle Park, NC 27709, USA.
Wang T; Integrative Bioinformatics Support Group, National Institutes of Health, Research Triangle Park, NC 27709, USA.
Grimm SA; Integrative Bioinformatics Support Group, National Institutes of Health, Research Triangle Park, NC 27709, USA.
Godfrey V; National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.
Waidyanatha S; National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.
Woychik RP; Genome Integrity and Structural Biology Laboratory, National Institutes of Health, Research Triangle Park, NC 27709, USA. Electronic address: rick.woychik@nih.gov.
Santos JH; Genome Integrity and Structural Biology Laboratory, National Institutes of Health, Research Triangle Park, NC 27709, USA; National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA. Electronic address: janine

Cell Rep ; 32(11): 108131, 2020 09 15.

Article en En | MEDLINE | ID: mdl-32937126

Asunto(s)

ADN Mitocondrial/efectos de los fármacos; Epigénesis Genética/efectos de los fármacos; Regulación de la Expresión Génica/efectos de los fármacos; Animales; Metilación de ADN/genética; ADN Mitocondrial/genética; Epigénesis Genética/genética; Epigenómica; Femenino; Expresión Génica/efectos de los fármacos; Exposición Materna/efectos adversos; Ratones; Ratones Endogámicos C57BL; Mitocondrias/efectos de los fármacos; Mitocondrias/metabolismo; Nucleótidos/genética; Rotenona/efectos adversos; Rotenona/farmacología

Palabras clave

DNA methylation; complex I; developmental exposure; epigenetics; gene expression; mitochondria; toxicant

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: ADN Mitocondrial / Regulación de la Expresión Génica / Epigénesis Genética Límite: Animals Idioma: En Revista: Cell Rep Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos

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