Efficacy of omalizumab treatment for pediatric chronic spontaneous urticaria: A multi-center retrospective case series.
Pediatr Dermatol
; 37(6): 1051-1054, 2020 Nov.
Article
en En
| MEDLINE
| ID: mdl-32951239
ABSTRACT
BACKGROUND:
Chronic urticaria is defined by the presence of itchy wheals, sometimes accompanied by angioedema, lasting for at least 6 weeks. In children, most cases occur without an eliciting factor and are defined as chronic spontaneous urticaria (CSU). CSU affects up to 0.75% of children with a negative impact on quality of life and school performance. CSU is treated in adults with second-generation antihistamines, increased up to four times normal doses for second-line treatment. Omalizumab (a monoclonal antibody to IgE) may be recommended as third-line therapy. A similar protocol is used in children, yet little is known of its efficacy and safety.OBJECTIVES:
To summarize our multi-center experience in treating children with recalcitrant CSU with omalizumab.METHODS:
A retrospective multi-center case series conducted in 5 tertiary care centers in Israel. Patients included were children <18 years old diagnosed with recalcitrant CSU who were treated with omalizumab. Patients were followed up throughout the duration of omalizumab therapy/symptom remission. Patients' electronic medical records were used to gather data.RESULTS:
Nineteen participants (11 F; 8 M) presented with CSU between ages 6 and 16.9 years. Sixteen (84%) responded to omalizumab, including children <12 years old, although two became non-responsive after 6-12 months of therapy. Another three patients (16%) were resistant to treatment, achieving remission through fourth-line (Cyclosporine A) or other therapies.CONCLUSION:
Children with recalcitrant CSU, even those <12 years old, respond well to standard-dose, third-line omalizumab therapy at rates similar to adults. Yet, some cases may become non-responsive with ongoing treatment.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Urticaria
/
Antialérgicos
/
Urticaria Crónica
Tipo de estudio:
Guideline
/
Observational_studies
Límite:
Adolescent
/
Adult
/
Child
/
Humans
País/Región como asunto:
Asia
Idioma:
En
Revista:
Pediatr Dermatol
Año:
2020
Tipo del documento:
Article
País de afiliación:
Israel