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Clinical outcomes of otogenic skull base osteomyelitis.
Jung, Da Jung; Hong, Jisong; Cho, Hyung Joon; Yoo, Myung Hoon; Lee, Kyu-Yup.
Afiliación
  • Jung DJ; Department of Otorhinolaryngology-Head and Neck Surgery, School of Medicine, Kyungpook National University, 200 Dongdeok-ro, Jung-gu, Daegu, 700-721, Republic of Korea.
  • Hong J; Department of Otorhinolaryngology-Head and Neck Surgery, School of Medicine, Kyungpook National University, 200 Dongdeok-ro, Jung-gu, Daegu, 700-721, Republic of Korea.
  • Cho HJ; Department of Otorhinolaryngology-Head and Neck Surgery, School of Medicine, Kyungpook National University, 200 Dongdeok-ro, Jung-gu, Daegu, 700-721, Republic of Korea.
  • Yoo MH; Department of Otorhinolaryngology-Head and Neck Surgery, School of Medicine, Kyungpook National University, 200 Dongdeok-ro, Jung-gu, Daegu, 700-721, Republic of Korea.
  • Lee KY; Department of Otorhinolaryngology-Head and Neck Surgery, School of Medicine, Kyungpook National University, 200 Dongdeok-ro, Jung-gu, Daegu, 700-721, Republic of Korea. kylee@knu.ac.kr.
Eur Arch Otorhinolaryngol ; 278(8): 2817-2822, 2021 Aug.
Article en En | MEDLINE | ID: mdl-32960351
ABSTRACT

PURPOSE:

Skull base osteomyelitis (SBO) is an uncommon and a potentially life-threatening condition if not promptly recognized and properly treated. The aim of our study was to present a 32-case series of patients diagnosed with SBO at a single center.

METHODS:

In this retrospective study, we reviewed the data of patients diagnosed with otogenic SBO between January 2011 and January 2020. 32 patients were enrolled in the study. SBO diagnosis was based on a combination of symptoms and physical examination, bone scan, brain magnetic resonance imaging, and pathologic examination findings. The following clinical data were collected during the follow-up period types of antibiotics used, duration of antibiotic treatment, C-reactive protein level, presence of disease control, duration from the onset of symptoms to diagnosis, and patient survival.

RESULTS:

The mean follow-up period was 11 (1-110) months. The mean duration of antibiotic treatment was 115 (19-223) days. The mean C-reactive protein levels at the time of diagnosis and at the endpoint of follow-up were 3.05 (0.56-18.31) and 0.21 (0.03-33.61) mg/dL, respectively (P < 0.001). Disease control rate was 34.9% at 1-year and 83.7% at 5-year follow-up. Patient survival rate was 90.6% at 1- and 3-year follow-ups. At the endpoint of follow-up, three patients died. The mean durations from the onset of symptoms to diagnosis were 50 (5-360) and 90 (30-480) days in patients with the controlled disease and in those with the uncontrolled disease, respectively, at the endpoint of follow-up (P = 0.043).

CONCLUSION:

Comprehensive assessment and aggressive treatment of patients exhibiting symptoms suggestive of SBO would help in the rapid diagnosis of otogenic SBO, resulting in an improvement in prognosis.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Osteomielitis / Base del Cráneo Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies Límite: Humans Idioma: En Revista: Eur Arch Otorhinolaryngol Asunto de la revista: OTORRINOLARINGOLOGIA Año: 2021 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Osteomielitis / Base del Cráneo Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies Límite: Humans Idioma: En Revista: Eur Arch Otorhinolaryngol Asunto de la revista: OTORRINOLARINGOLOGIA Año: 2021 Tipo del documento: Article