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A Comparative Study of the Pharmacokinetics of Bis- and Pentaphosphonic Acids Labeled with Gallium-68 in Rats with Experimental Model of Bone Callus.
Tishchenko, V K; Petriev, V M; Kuzenkova, K A; Shegai, P V; Ivanov, S A; Kaprin, A D.
Afiliación
  • Tishchenko VK; National Medical Research Center of Radiology, Ministry of Health of the Russian Federation, Obninsk, Russia. vikshir82@mail.ru.
  • Petriev VM; National Research Nuclear University MEPhI (Moscow Engineering Physics Institute), Moscow, Russia. vikshir82@mail.ru.
  • Kuzenkova KA; National Medical Research Center of Radiology, Ministry of Health of the Russian Federation, Obninsk, Russia.
  • Shegai PV; National Research Nuclear University MEPhI (Moscow Engineering Physics Institute), Moscow, Russia.
  • Ivanov SA; National Medical Research Center of Radiology, Ministry of Health of the Russian Federation, Obninsk, Russia.
  • Kaprin AD; National Medical Research Center of Radiology, Ministry of Health of the Russian Federation, Obninsk, Russia.
Bull Exp Biol Med ; 169(5): 644-647, 2020 Sep.
Article en En | MEDLINE | ID: mdl-32986215
ABSTRACT
We analyzed biodistribution of 68Ga-labeled hydroxyethylidenediphosphonic acid (68Ga-HEDP) and diethylenetriaminepentakis(methylenephosphonic acid) (68Ga-DTPMP) in Wistar rats with experimental model of bone callus. It was shown that the content of 68Ga-DTPMP and 68Ga-HEDP in bone callus was ~1.5-fold higher than in intact femur. 68Ga-DTPMP was characterized by higher stability in vivo, higher uptake in the bone tissue, and lower uptake in others visceral organs in comparison with 68Ga-HEDP. Thus, 68Ga-DTPMP had more suitable pharmacokinetic properties than 68Ga-HEDP.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Huesos / Callo Óseo / Difosfonatos / Radioisótopos de Galio Límite: Animals Idioma: En Revista: Bull Exp Biol Med Año: 2020 Tipo del documento: Article País de afiliación: Rusia
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Huesos / Callo Óseo / Difosfonatos / Radioisótopos de Galio Límite: Animals Idioma: En Revista: Bull Exp Biol Med Año: 2020 Tipo del documento: Article País de afiliación: Rusia