Asymmetric Biocatalytic Synthesis of 1-Aryltetrahydro-ß-carbolines Enabled by "Substrate Walking".

Eger, Elisabeth; Schrittwieser, Joerg H; Wetzl, Dennis; Iding, Hans; Kuhn, Bernd; Kroutil, Wolfgang

Eger, Elisabeth; Schrittwieser, Joerg H; Wetzl, Dennis; Iding, Hans; Kuhn, Bernd; Kroutil, Wolfgang.

Afiliación

Eger E; Institute of Chemistry, Biocatalytic Synthesis, University of Graz, NAWI Graz, BioTechMed Graz, Heinrichstrasse 28/II, 8010, Graz, Austria.
Schrittwieser JH; Institute of Chemistry, Biocatalytic Synthesis, University of Graz, NAWI Graz, BioTechMed Graz, Heinrichstrasse 28/II, 8010, Graz, Austria.
Wetzl D; Process Chemistry & Catalysis, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070, Basel, Switzerland.
Iding H; Process Chemistry & Catalysis, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070, Basel, Switzerland.
Kuhn B; Pharma Research & Early Development, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070, Basel, Switzerland.
Kroutil W; Institute of Chemistry, Biocatalytic Synthesis, University of Graz, NAWI Graz, BioTechMed Graz, Heinrichstrasse 28/II, 8010, Graz, Austria.

Chemistry ; 26(69): 16281-16285, 2020 Dec 09.

Article en En | MEDLINE | ID: mdl-33017078

Asunto(s)

Carbolinas; Caminata; Biocatálisis; Catálisis; Estereoisomerismo

Palabras clave

Pictet-Spengler reaction; asymmetric catalysis; biocatalysis; carbolines; enzyme engineering

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Carbolinas / Caminata Idioma: En Revista: Chemistry Asunto de la revista: QUIMICA Año: 2020 Tipo del documento: Article País de afiliación: Austria

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