Discovery of Novel Fetal Hemoglobin Inducers through Small Chemical Library Screening.

Breveglieri, Giulia; Pacifico, Salvatore; Zuccato, Cristina; Cosenza, Lucia Carmela; Sultan, Shaiq; D'Aversa, Elisabetta; Gambari, Roberto; Preti, Delia; Trapella, Claudio; Guerrini, Remo; Borgatti, Monica

Breveglieri, Giulia; Pacifico, Salvatore; Zuccato, Cristina; Cosenza, Lucia Carmela; Sultan, Shaiq; D'Aversa, Elisabetta; Gambari, Roberto; Preti, Delia; Trapella, Claudio; Guerrini, Remo; Borgatti, Monica.

Afiliación

Breveglieri G; Department of Life Sciences and Biotechnology, University of Ferrara, Via Fossato di Mortara 74, 44121 Ferrara, Italy.
Pacifico S; Department of Chemical and Pharmaceutical Sciences, University of Ferrara, Via Luigi Borsari 46, 44121 Ferrara, Italy.
Zuccato C; Department of Life Sciences and Biotechnology, University of Ferrara, Via Fossato di Mortara 74, 44121 Ferrara, Italy.
Cosenza LC; Department of Life Sciences and Biotechnology, University of Ferrara, Via Fossato di Mortara 74, 44121 Ferrara, Italy.
Sultan S; Department of Life Sciences and Biotechnology, University of Ferrara, Via Fossato di Mortara 74, 44121 Ferrara, Italy.
D'Aversa E; Department of Life Sciences and Biotechnology, University of Ferrara, Via Fossato di Mortara 74, 44121 Ferrara, Italy.
Gambari R; Department of Life Sciences and Biotechnology, University of Ferrara, Via Fossato di Mortara 74, 44121 Ferrara, Italy.
Preti D; Department of Chemical and Pharmaceutical Sciences, University of Ferrara, Via Luigi Borsari 46, 44121 Ferrara, Italy.
Trapella C; Department of Chemical and Pharmaceutical Sciences, University of Ferrara, Via Luigi Borsari 46, 44121 Ferrara, Italy.
Guerrini R; Department of Chemical and Pharmaceutical Sciences, University of Ferrara, Via Luigi Borsari 46, 44121 Ferrara, Italy.
Borgatti M; Department of Life Sciences and Biotechnology, University of Ferrara, Via Fossato di Mortara 74, 44121 Ferrara, Italy.

Int J Mol Sci ; 21(19)2020 Oct 08.

Article en En | MEDLINE | ID: mdl-33050052

Asunto(s)

Anemia de Células Falciformes/sangre; Descubrimiento de Drogas/métodos; Hemoglobina Fetal/biosíntesis; Biosíntesis de Proteínas/efectos de los fármacos; Bibliotecas de Moléculas Pequeñas/farmacología; Talasemia beta/sangre; Anemia de Células Falciformes/tratamiento farmacológico; Técnicas Biosensibles/métodos; Diferenciación Celular/efectos de los fármacos; Proliferación Celular/efectos de los fármacos; Evaluación Preclínica de Medicamentos/métodos; Citometría de Flujo; Expresión Génica/efectos de los fármacos; Regulación de la Expresión Génica/efectos de los fármacos; Proteínas Fluorescentes Verdes/genética; Humanos; Células K562; Proteínas Luminiscentes/genética; Bibliotecas de Moléculas Pequeñas/uso terapéutico; Globinas beta/genética; Talasemia beta/tratamiento farmacológico; gamma-Globinas/genética; Proteína Fluorescente Roja

Palabras clave

cellular biosensors; chemical screening; compound library; fetal hemoglobin; hemoglobinopathies; sickle cell disease; ß-thalassemia

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Biosíntesis de Proteínas / Hemoglobina Fetal / Talasemia beta / Bibliotecas de Moléculas Pequeñas / Descubrimiento de Drogas / Anemia de Células Falciformes Tipo de estudio: Diagnostic_studies / Screening_studies Límite: Humans Idioma: En Revista: Int J Mol Sci Año: 2020 Tipo del documento: Article País de afiliación: Italia

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google