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A high-stringency blueprint of the human proteome.
Adhikari, Subash; Nice, Edouard C; Deutsch, Eric W; Lane, Lydie; Omenn, Gilbert S; Pennington, Stephen R; Paik, Young-Ki; Overall, Christopher M; Corrales, Fernando J; Cristea, Ileana M; Van Eyk, Jennifer E; Uhlén, Mathias; Lindskog, Cecilia; Chan, Daniel W; Bairoch, Amos; Waddington, James C; Justice, Joshua L; LaBaer, Joshua; Rodriguez, Henry; He, Fuchu; Kostrzewa, Markus; Ping, Peipei; Gundry, Rebekah L; Stewart, Peter; Srivastava, Sanjeeva; Srivastava, Sudhir; Nogueira, Fabio C S; Domont, Gilberto B; Vandenbrouck, Yves; Lam, Maggie P Y; Wennersten, Sara; Vizcaino, Juan Antonio; Wilkins, Marc; Schwenk, Jochen M; Lundberg, Emma; Bandeira, Nuno; Marko-Varga, Gyorgy; Weintraub, Susan T; Pineau, Charles; Kusebauch, Ulrike; Moritz, Robert L; Ahn, Seong Beom; Palmblad, Magnus; Snyder, Michael P; Aebersold, Ruedi; Baker, Mark S.
Afiliación
  • Adhikari S; Faculty of Medicine, Health and Human Sciences, Department of Biomedical Sciences, Macquarie University, North Ryde, NSW, 2109, Australia.
  • Nice EC; Faculty of Medicine, Health and Human Sciences, Department of Biomedical Sciences, Macquarie University, North Ryde, NSW, 2109, Australia.
  • Deutsch EW; Faculty of Medicine, Nursing and Health Sciences, Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC, 3800, Australia.
  • Lane L; Institute for Systems Biology, 401 Terry Avenue North, Seattle, WA, 98109, USA.
  • Omenn GS; Faculty of Medicine, SIB-Swiss Institute of Bioinformatics and Department of Microbiology and Molecular Medicine, University of Geneva, CMU, Michel-Servet 1, 1211, Geneva, Switzerland.
  • Pennington SR; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, 48109-2218, USA.
  • Paik YK; UCD Conway Institute of Biomolecular and Biomedical Research, School of Medicine, University College Dublin, Dublin, Ireland.
  • Overall CM; Yonsei Proteome Research Center, 50 Yonsei-ro, Sudaemoon-ku, Seoul, 120-749, South Korea.
  • Corrales FJ; Faculty of Dentistry, University of British Columbia, Vancouver, BC, Canada.
  • Cristea IM; Functional Proteomics Laboratory, Centro Nacional de Biotecnología-CSIC, Proteored-ISCIII, 28049, Madrid, Spain.
  • Van Eyk JE; Department of Molecular Biology, Princeton University, Princeton, NJ, 08544, USA.
  • Uhlén M; Cedars Sinai Medical Center, Advanced Clinical Biosystems Research Institute, The Smidt Heart Institute, Los Angeles, CA, 90048, USA.
  • Lindskog C; Science for Life Laboratory, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, 17121, Solna, Sweden.
  • Chan DW; Rudbeck Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, 75185, Uppsala, Sweden.
  • Bairoch A; Department of Pathology and Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, 21224, USA.
  • Waddington JC; Faculty of Medicine, SIB-Swiss Institute of Bioinformatics and Department of Microbiology and Molecular Medicine, University of Geneva, CMU, Michel-Servet 1, 1211, Geneva, Switzerland.
  • Justice JL; UCD Conway Institute of Biomolecular and Biomedical Research, School of Medicine, University College Dublin, Dublin, Ireland.
  • LaBaer J; Department of Molecular Biology, Princeton University, Princeton, NJ, 08544, USA.
  • Rodriguez H; Biodesign Institute, Arizona State University, Tempe, AZ, USA.
  • He F; Office of Cancer Clinical Proteomics Research, National Cancer Institute, NIH, Bethesda, MD, 20892, USA.
  • Kostrzewa M; State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, 102206, China.
  • Ping P; Bruker Daltonik GmbH, Microbiology and Diagnostics, Fahrenheitstrasse, 428359, Bremen, Germany.
  • Gundry RL; Cardiac Proteomics and Signaling Laboratory, Department of Physiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
  • Stewart P; CardiOmics Program, Center for Heart and Vascular Research, Division of Cardiovascular Medicine and Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
  • Srivastava S; Department of Chemical Pathology, Royal Prince Alfred Hospital, Camperdown, NSW, Australia.
  • Srivastava S; Indian Institute of Technology Bombay, Powai, Mumbai, 400076, India.
  • Nogueira FCS; Cancer Biomarkers Research Branch, National Cancer Institute, National Institutes of Health, 9609 Medical Center Drive, Suite 5E136, Rockville, MD, 20852, USA.
  • Domont GB; Proteomics Unit and Laboratory of Proteomics, Institute of Chemistry, Federal University of Rio de Janeiro, Av Athos da Silveria Ramos, 149, 21941-909, Rio de Janeiro, RJ, Brazil.
  • Vandenbrouck Y; Proteomics Unit and Laboratory of Proteomics, Institute of Chemistry, Federal University of Rio de Janeiro, Av Athos da Silveria Ramos, 149, 21941-909, Rio de Janeiro, RJ, Brazil.
  • Lam MPY; University of Grenoble Alpes, Inserm, CEA, IRIG-BGE, U1038, 38000, Grenoble, France.
  • Wennersten S; Departments of Medicine-Cardiology and Biochemistry and Molecular Genetics, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.
  • Vizcaino JA; Consortium for Fibrosis Research and Translation, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.
  • Wilkins M; Division of Cardiology, Department of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.
  • Schwenk JM; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.
  • Lundberg E; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, Australia.
  • Bandeira N; Science for Life Laboratory, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, 17121, Solna, Sweden.
  • Marko-Varga G; Science for Life Laboratory, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, 17121, Solna, Sweden.
  • Weintraub ST; Department of Computer Science and Engineering, University of California, San Diego, 9500 Gilman Drive, Mail Code 0404, La Jolla, CA, 92093-0404, USA.
  • Pineau C; Department of Biomedical Engineering, Lund University, Lund, Sweden.
  • Kusebauch U; Department of Biochemistry and Structural Biology, University of Texas Health Science Center San Antonio, UT Health, 7703 Floyd Curl Drive, San Antonio, TX, 78229-3900, USA.
  • Moritz RL; University of Rennes, Inserm, EHESP, IREST, UMR_S 1085, F-35042, Rennes, France.
  • Ahn SB; Institute for Systems Biology, 401 Terry Avenue North, Seattle, WA, 98109, USA.
  • Palmblad M; Institute for Systems Biology, 401 Terry Avenue North, Seattle, WA, 98109, USA.
  • Snyder MP; Faculty of Medicine, Health and Human Sciences, Department of Biomedical Sciences, Macquarie University, North Ryde, NSW, 2109, Australia.
  • Aebersold R; Leiden University Medical Center, Leiden, 2333, The Netherlands.
  • Baker MS; Department of Genetics, Stanford School of Medicine, Stanford, CA, 94305, USA.
Nat Commun ; 11(1): 5301, 2020 10 16.
Article en En | MEDLINE | ID: mdl-33067450
ABSTRACT
The Human Proteome Organization (HUPO) launched the Human Proteome Project (HPP) in 2010, creating an international framework for global collaboration, data sharing, quality assurance and enhancing accurate annotation of the genome-encoded proteome. During the subsequent decade, the HPP established collaborations, developed guidelines and metrics, and undertook reanalysis of previously deposited community data, continuously increasing the coverage of the human proteome. On the occasion of the HPP's tenth anniversary, we here report a 90.4% complete high-stringency human proteome blueprint. This knowledge is essential for discerning molecular processes in health and disease, as we demonstrate by highlighting potential roles the human proteome plays in our understanding, diagnosis and treatment of cancers, cardiovascular and infectious diseases.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Enfermedad / Proteoma Tipo de estudio: Guideline Límite: Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2020 Tipo del documento: Article País de afiliación: Australia
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Enfermedad / Proteoma Tipo de estudio: Guideline Límite: Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2020 Tipo del documento: Article País de afiliación: Australia