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Scalable Synthesis, In Vitro cccDNA Reduction, and In Vivo Antihepatitis B Virus Activity of a Phosphonomethoxydeoxythreosyl Adenine Prodrug.
Luo, Min; Wu, Shuo; Kalkeri, Raj; Ptak, Roger G; Zhou, Tianlun; Van Mellaert, Lieve; Wang, Chuanmin; Dumbre, Shrinivas G; Block, Timothy; Groaz, Elisabetta; De Jonghe, Steven; Li, Yuhuan; Herdewijn, Piet.
Afiliación
  • Luo M; Medicinal Chemistry, KU Leuven, Rega Institute for Medical Research, Herestraat 49-box 1041, 3000 Leuven, Belgium.
  • Wu S; CAMS Key Laboratory of Antiviral Drug Research, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 1, Tiantan Xili, 100050 Beijing, China.
  • Kalkeri R; Department of Infectious Disease Research, Southern Research Institute, 431 Aviation Way, Frederick, Maryland 21701, United States.
  • Ptak RG; Department of Infectious Disease Research, Southern Research Institute, 431 Aviation Way, Frederick, Maryland 21701, United States.
  • Zhou T; Baruch S. Blumberg Institute, Doylestown, Pennsylvania 18902, United States.
  • Van Mellaert L; Department of Microbiology, Immunology and Transplantation, Laboratory of Molecular Bacteriology, KU Leuven, Rega Institute for Medical Research, Herestraat 49-box 1037, 3000 Leuven, Belgium.
  • Wang C; Department of Infectious Diseases, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, China.
  • Dumbre SG; Medicinal Chemistry, KU Leuven, Rega Institute for Medical Research, Herestraat 49-box 1041, 3000 Leuven, Belgium.
  • Block T; Baruch S. Blumberg Institute, Doylestown, Pennsylvania 18902, United States.
  • Groaz E; Medicinal Chemistry, KU Leuven, Rega Institute for Medical Research, Herestraat 49-box 1041, 3000 Leuven, Belgium.
  • De Jonghe S; Department of Microbiology, Immunology and Transplantation, Laboratory of Virology and Chemotherapy, KU Leuven, Rega Institute for Medical Research, Herestraat 49-box 1043, 3000 Leuven, Belgium.
  • Li Y; CAMS Key Laboratory of Antiviral Drug Research, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 1, Tiantan Xili, 100050 Beijing, China.
  • Herdewijn P; Medicinal Chemistry, KU Leuven, Rega Institute for Medical Research, Herestraat 49-box 1041, 3000 Leuven, Belgium.
J Med Chem ; 63(22): 13851-13860, 2020 11 25.
Article en En | MEDLINE | ID: mdl-33191744
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Antivirales / ADN Circular / Profármacos / Virus de la Hepatitis B / Farmacorresistencia Viral / Guanina / Hepatitis B Límite: Animals Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2020 Tipo del documento: Article País de afiliación: Bélgica
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Antivirales / ADN Circular / Profármacos / Virus de la Hepatitis B / Farmacorresistencia Viral / Guanina / Hepatitis B Límite: Animals Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2020 Tipo del documento: Article País de afiliación: Bélgica