Adding flexibility to clinical trial designs: an example-based guide to the practical use of adaptive designs.

Burnett, Thomas; Mozgunov, Pavel; Pallmann, Philip; Villar, Sofia S; Wheeler, Graham M; Jaki, Thomas

Burnett, Thomas; Mozgunov, Pavel; Pallmann, Philip; Villar, Sofia S; Wheeler, Graham M; Jaki, Thomas.

Afiliación

Burnett T; Department of Mathematics and Statistics, Lancaster University, Fylde College, Lancaster, LA1 4YF, UK. t.burnett1@lancaster.ac.uk.
Mozgunov P; Department of Mathematics and Statistics, Lancaster University, Fylde College, Lancaster, LA1 4YF, UK.
Pallmann P; Centre for Trials Research, College of Biomedical & Life Sciences, Cardiff University, Cardiff, UK.
Villar SS; MRC Biostatistics Unit, University of Cambridge School of Clinical Medicine, Cambridge Institute of Public Health, Forvie Site, Robinson Way, Cambridge Biomedical Campus, Cambridge, CB2 0SR, UK.
Wheeler GM; Cancer Research UK & UCL Cancer Trials Centre, University College London, 90 Tottenham Court Road, London, W1T 4TJ, UK.
Jaki T; Department of Mathematics and Statistics, Lancaster University, Fylde College, Lancaster, LA1 4YF, UK.

BMC Med ; 18(1): 352, 2020 11 19.

Article en En | MEDLINE | ID: mdl-33208155

Asunto(s)

Proyectos de Investigación; Ensayos Clínicos como Asunto; Humanos; Estudios Prospectivos; Tamaño de la Muestra

Palabras clave

Efficient methods; Enrichment designs; Innovative trials; Multi-arm multi-stage platform trials; Novel designs

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proyectos de Investigación Tipo de estudio: Clinical_trials / Observational_studies Límite: Humans Idioma: En Revista: BMC Med Asunto de la revista: MEDICINA Año: 2020 Tipo del documento: Article País de afiliación: Reino Unido

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