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Circulating miRNA Spaceflight Signature Reveals Targets for Countermeasure Development.
Malkani, Sherina; Chin, Christopher R; Cekanaviciute, Egle; Mortreux, Marie; Okinula, Hazeem; Tarbier, Marcel; Schreurs, Ann-Sofie; Shirazi-Fard, Yasaman; Tahimic, Candice G T; Rodriguez, Deyra N; Sexton, Brittany S; Butler, Daniel; Verma, Akanksha; Bezdan, Daniela; Durmaz, Ceyda; MacKay, Matthew; Melnick, Ari; Meydan, Cem; Li, Sheng; Garrett-Bakelman, Francine; Fromm, Bastian; Afshinnekoo, Ebrahim; Langhorst, Brad W; Dimalanta, Eileen T; Cheng-Campbell, Margareth; Blaber, Elizabeth; Schisler, Jonathan C; Vanderburg, Charles; Friedländer, Marc R; McDonald, J Tyson; Costes, Sylvain V; Rutkove, Seward; Grabham, Peter; Mason, Christopher E; Beheshti, Afshin.
Afiliación
  • Malkani S; Blue Marble Space Institute of Science, Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA 94035, USA.
  • Chin CR; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.
  • Cekanaviciute E; Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA 94035, USA.
  • Mortreux M; Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Okinula H; Center for Radiological Research, Columbia University, New York, NY 10032, USA.
  • Tarbier M; Science for Life Laboratory, Department of Molecular Biosciences, the Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.
  • Schreurs AS; KBR, Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA 94035, USA.
  • Shirazi-Fard Y; Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA 94035, USA.
  • Tahimic CGT; KBR, Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA 94035, USA.
  • Rodriguez DN; New England Biolabs, Ipswich, MA, USA.
  • Sexton BS; New England Biolabs, Ipswich, MA, USA.
  • Butler D; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.
  • Verma A; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.
  • Bezdan D; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA; Institute of Medical Virology and Epidemiology of Viral Diseases, University
  • Durmaz C; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.
  • MacKay M; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.
  • Melnick A; Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
  • Meydan C; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.
  • Li S; The Jackson Laboratories, Farmington, CT, USA.
  • Garrett-Bakelman F; Department of Medicine, Weill Cornell Medicine, New York, NY, USA; Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA, USA; Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA, USA.
  • Fromm B; Science for Life Laboratory, Department of Molecular Biosciences, the Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.
  • Afshinnekoo E; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.
  • Langhorst BW; New England Biolabs, Ipswich, MA, USA.
  • Dimalanta ET; New England Biolabs, Ipswich, MA, USA.
  • Cheng-Campbell M; Center for Biotechnology & Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.
  • Blaber E; Center for Biotechnology & Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY 12180, USA; Universities Space Research Association, Space Biosciences Division, NASA Ames Research Center, Mountain View, CA 94035, USA.
  • Schisler JC; McAllister Heart Institute, Department of Pharmacology, and Department of Pathology and Lab Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  • Vanderburg C; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Friedländer MR; Science for Life Laboratory, Department of Molecular Biosciences, the Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.
  • McDonald JT; Department of Radiation Medicine, Georgetown University School of Medicine, Washington DC 20007, USA.
  • Costes SV; Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA 94035, USA.
  • Rutkove S; Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Grabham P; Center for Radiological Research, Columbia University, New York, NY 10032, USA.
  • Mason CE; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA; The WorldQuant Initiative for Quantitative Prediction, Weill Cornell Medicine
  • Beheshti A; KBR, Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA 94035, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address: afshin.beheshti@nasa.gov.
Cell Rep ; 33(10): 108448, 2020 12 08.
Article en En | MEDLINE | ID: mdl-33242410
We have identified and validated a spaceflight-associated microRNA (miRNA) signature that is shared by rodents and humans in response to simulated, short-duration and long-duration spaceflight. Previous studies have identified miRNAs that regulate rodent responses to spaceflight in low-Earth orbit, and we have confirmed the expression of these proposed spaceflight-associated miRNAs in rodents reacting to simulated spaceflight conditions. Moreover, astronaut samples from the NASA Twins Study confirmed these expression signatures in miRNA sequencing, single-cell RNA sequencing (scRNA-seq), and single-cell assay for transposase accessible chromatin (scATAC-seq) data. Additionally, a subset of these miRNAs (miR-125, miR-16, and let-7a) was found to regulate vascular damage caused by simulated deep space radiation. To demonstrate the physiological relevance of key spaceflight-associated miRNAs, we utilized antagomirs to inhibit their expression and successfully rescue simulated deep-space-radiation-mediated damage in human 3D vascular constructs.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Ingravidez / MicroARNs / MicroARN Circulante Límite: Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Cell Rep Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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PubMed Links
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Ingravidez / MicroARNs / MicroARN Circulante Límite: Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Cell Rep Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos