Amlodipine alleviates cisplatin-induced nephrotoxicity in rats through gamma-glutamyl transpeptidase (GGT) enzyme inhibition, associated with regulation of Nrf2/HO-1, MAPK/NF-κB, and Bax/Bcl-2 signaling.
Saudi Pharm J
; 28(11): 1317-1325, 2020 Nov.
Article
en En
| MEDLINE
| ID: mdl-33250641
Amlodipine; Anti-inflammatory response; Anti-oxidant defense; BUN, Blood urea nitrogen; Bax, Bcl-2-associated X protein; Bcl-2, B-cell lymphoma 2; CMC, Carboxymethyl cellulose; Cisplatin nephrotoxicity; GGT inhibition; GGT, gamma-glutamyl transpeptidase; GSH, Reduced glutathione; H & E, Hematoxylin and eosin; HGF, Hepatocyte growth factor; HO-1, Heme oxygenase-1; IL-6, Interleukin-6; Keap1, Kelch-like ECH-associated protein 1; MAPK, Mitogen-activated protein kinase; MDA, Malondialdehyde; NADPH, Nicotinamide adenine dinucleotide phosphate; NF-κB, Nuclear factor-kappa B; NO, Nitric oxide; NOx, Total nitrate/nitrite; Nrf2, Nuclear factor erythroid 2-related factor 2; ROS, Reactive oxygen species; Renal cell survival; TNF-α, Tumor necrosis factor-alpha; VCAM-1, vascular cell adhesion molecule-1
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1
Colección:
01-internacional
Banco de datos:
MEDLINE
Tipo de estudio:
Risk_factors_studies
Idioma:
En
Revista:
Saudi Pharm J
Año:
2020
Tipo del documento:
Article
País de afiliación:
Egipto