The role of glycosylation in the N-terminus of the hemagglutinin of a unique H4N2 with a natural polybasic cleavage site in virus fitness <i>in vitro</i> and <i>in vivo</i>.

Gischke, Marcel; Bagato, Ola; Breithaupt, Angele; Scheibner, David; Blaurock, Claudia; Vallbracht, Melina; Karger, Axel; Crossley, Beate; Veits, Jutta; Böttcher-Friebertshäuser, Eva; Mettenleiter, Thomas C; Abdelwhab, Elsayed M

The role of glycosylation in the N-terminus of the hemagglutinin of a unique H4N2 with a natural polybasic cleavage site in virus fitness in vitro and in vivo.

Gischke, Marcel; Bagato, Ola; Breithaupt, Angele; Scheibner, David; Blaurock, Claudia; Vallbracht, Melina; Karger, Axel; Crossley, Beate; Veits, Jutta; Böttcher-Friebertshäuser, Eva; Mettenleiter, Thomas C; Abdelwhab, Elsayed M.

Afiliación

Gischke M; Institute of Molecular Virology and Cell Biology, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health , Greifswald-Insel Riems, Germany.
Bagato O; Institute of Molecular Virology and Cell Biology, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health , Greifswald-Insel Riems, Germany.
Breithaupt A; Center of Scientific Excellence for Influenza Viruses, National Research Centre (NRC) , Dokki, Giza, Egypt.
Scheibner D; Department of Experimental Animal Facilities and Biorisk Management, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health , Greifswald-Insel Riems, Germany.
Blaurock C; Institute of Molecular Virology and Cell Biology, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health , Greifswald-Insel Riems, Germany.
Vallbracht M; Institute of Molecular Virology and Cell Biology, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health , Greifswald-Insel Riems, Germany.
Karger A; Institute of Molecular Virology and Cell Biology, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health , Greifswald-Insel Riems, Germany.
Crossley B; Institute of Molecular Virology and Cell Biology, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health , Greifswald-Insel Riems, Germany.
Veits J; California Animal Health and Food Safety Laboratory, School of Veterinary Medicine, University of California , Davis, United States.
Böttcher-Friebertshäuser E; Institute of Molecular Virology and Cell Biology, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health , Greifswald-Insel Riems, Germany.
Mettenleiter TC; Institute of Virology, Philipps University Marburg , Marburg, Germany.
Abdelwhab EM; Institute of Molecular Virology and Cell Biology, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health , Greifswald-Insel Riems, Germany.

Virulence ; 12(1): 666-678, 2021 12.

Article en En | MEDLINE | ID: mdl-33538209

Asunto(s)

Aptitud Genética; Hemaglutininas Virales/metabolismo; Virus de la Influenza A/genética; Virus de la Influenza A/metabolismo; Animales; Encéfalo/virología; Embrión de Pollo; Pollos; Perros; Femenino; Glicosilación; Hemaglutininas Virales/química; Hemaglutininas Virales/genética; Virus de la Influenza A/química; Virus de la Influenza A/clasificación; Células de Riñón Canino Madin Darby; Masculino; Aves de Corral; Tropismo Viral; Virulencia; Replicación Viral

Palabras clave

Highly pathogenic; avian influenza virus; glycosylation; h4n2; hemagglutinin; low pathogenic; non-H5/H7; proteolytic activation; transmission; virulence

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Virus de la Influenza A / Aptitud Genética / Hemaglutininas Virales Tipo de estudio: Risk_factors_studies Límite: Animals Idioma: En Revista: Virulence Año: 2021 Tipo del documento: Article País de afiliación: Alemania

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