Dydrogesterone Affects the Transcription of Genes in Innate Immune and Coagulation Cascade in Zebrafish Embryos.
Bull Environ Contam Toxicol
; 106(4): 594-599, 2021 Apr.
Article
en En
| MEDLINE
| ID: mdl-33570674
ABSTRACT
Dydrogesterone (DDG) acts on the reproduction but also affects the functioning of non-reproductive system. So far, the knowledge about other effects of DDG remains limited. Here we investigated the effects of DDG on the transcription of genes in innate immune and coagulation cascade in zebrafish embryos. The zebrafish embryos were exposed to DDG at 49.0, 527 and 5890 ng L- 1 for 144 hour post fertilization (hpf). The results showed that DDG significantly decreased the transcription of marker genes (e.g. tnfa, il8 and cc-chem) involved in the innate immune response at environmental concentrations. Moreover, DDG also down-regulated the transcription of genes in coagulation cascade (e.g. fga, fgb, fgg and f2). These results indicated that DDG had potential effects on the innate immune and coagulation cascade functions in the early life zebrafish, thus further affecting fish growth and health.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Contaminantes Químicos del Agua
/
Pez Cebra
Límite:
Animals
Idioma:
En
Revista:
Bull Environ Contam Toxicol
Año:
2021
Tipo del documento:
Article
País de afiliación:
China