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Bromelain inhibits SARS-CoV-2 infection via targeting ACE-2, TMPRSS2, and spike protein.
Sagar, Satish; Rathinavel, Ashok Kumar; Lutz, William E; Struble, Lucas R; Khurana, Surender; Schnaubelt, Andy T; Mishra, Nitish Kumar; Guda, Chittibabu; Palermo, Nicholas Y; Broadhurst, Mara J; Hoffmann, Tobias; Bayles, Kenneth W; Reid, St Patrick M; Borgstahl, Gloria E O; Radhakrishnan, Prakash.
Afiliación
  • Sagar S; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, USA.
  • Rathinavel AK; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, USA.
  • Lutz WE; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, USA.
  • Struble LR; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, USA.
  • Khurana S; Division of Viral Products, Center for Biologics Evaluation and Research (CBER), FDA, Silver Spring, Maryland, USA.
  • Schnaubelt AT; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
  • Mishra NK; Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, Nebraska, USA.
  • Guda C; Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, Nebraska, USA.
  • Palermo NY; Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska, USA.
  • Broadhurst MJ; Computational Chemistry Core, University of Nebraska Medical Center, Omaha, Nebraska, USA.
  • Hoffmann T; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
  • Bayles KW; Advanced Light and Electron Microscopy, Centre for Biological Threats and Special Pathogens 4 (ZBS 4), Robert Koch Institute, Berlin, Germany.
  • Reid SPM; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
  • Borgstahl GEO; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
  • Radhakrishnan P; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Clin Transl Med ; 11(2): e281, 2021 02.
Article en En | MEDLINE | ID: mdl-33635001
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Serina Endopeptidasas / Bromelaínas / Glicoproteína de la Espiga del Coronavirus / Enzima Convertidora de Angiotensina 2 / SARS-CoV-2 / COVID-19 / Tratamiento Farmacológico de COVID-19 Límite: Animals / Humans Idioma: En Revista: Clin Transl Med Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Serina Endopeptidasas / Bromelaínas / Glicoproteína de la Espiga del Coronavirus / Enzima Convertidora de Angiotensina 2 / SARS-CoV-2 / COVID-19 / Tratamiento Farmacológico de COVID-19 Límite: Animals / Humans Idioma: En Revista: Clin Transl Med Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos