Knockdown of TRIM32 inhibits tumor growth and increases the therapeutic sensitivity to temozolomide in glioma in a p53-dependent and -independent manner.

Cai, Yu; Gu, Wei Ting; Cheng, Kang; Jia, Pei Feng; Li, Feng; Wang, Ming; Zhang, Wei Feng; Qiu, Ji Ting; Wu, Zhe Bao; Zhao, Wei Guo

Cai, Yu; Gu, Wei Ting; Cheng, Kang; Jia, Pei Feng; Li, Feng; Wang, Ming; Zhang, Wei Feng; Qiu, Ji Ting; Wu, Zhe Bao; Zhao, Wei Guo.

Afiliación

Cai Y; Department of Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China; Department of Neurosurgery, Ruijin Hospital North, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Gu WT; Department of Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China; Department of Neurosurgery, Ruijin Hospital North, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Cheng K; Department of Neurosurgery, Ruijin Hospital North, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Jia PF; Department of Neurosurgery, Ruijin Hospital North, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Li F; Department of Neurosurgery, Ruijin Hospital North, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Wang M; Department of Neurosurgery, Ruijin Hospital North, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Zhang WF; Department of Neurosurgery, Ruijin Hospital North, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Qiu JT; Department of Neurosurgery, Ruijin Hospital North, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Wu ZB; Department of Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Zhao WG; Department of Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. Electronic address: ruijinzhaoweiguo@163.com.

Biochem Biophys Res Commun ; 550: 134-141, 2021 04 23.

Article en En | MEDLINE | ID: mdl-33691199

Asunto(s)

Proliferación Celular; Resistencia a Antineoplásicos; Glioma/tratamiento farmacológico; Glioma/patología; Temozolomida/uso terapéutico; Factores de Transcripción/deficiencia; Proteínas de Motivos Tripartitos/deficiencia; Proteína p53 Supresora de Tumor; Ubiquitina-Proteína Ligasas/deficiencia; Animales; Apoptosis/efectos de los fármacos; Apoptosis/genética; Proteínas Reguladoras de la Apoptosis/biosíntesis; Proteínas Reguladoras de la Apoptosis/genética; Línea Celular Tumoral; Resistencia a Antineoplásicos/genética; Regulación Neoplásica de la Expresión Génica; Técnicas de Silenciamiento del Gen; Glioma/genética; Humanos; Ratones; Terapia Molecular Dirigida; Clasificación del Tumor; Temozolomida/farmacología; Factores de Transcripción/biosíntesis; Factores de Transcripción/genética; Factores de Transcripción/metabolismo; Proteínas de Motivos Tripartitos/biosíntesis; Proteínas de Motivos Tripartitos/genética; Proteínas de Motivos Tripartitos/metabolismo; Proteína p53 Supresora de Tumor/biosíntesis; Proteína p53 Supresora de Tumor/deficiencia; Proteína p53 Supresora de Tumor/genética; Proteína p53 Supresora de Tumor/metabolismo; Ubiquitina-Proteína Ligasas/biosíntesis; Ubiquitina-Proteína Ligasas/genética; Ubiquitina-Proteína Ligasas/metabolismo; Regulación hacia Arriba; Ensayos Antitumor por Modelo de Xenoinjerto

Palabras clave

Cell proliferation; Glioma; TRIM32; Temozolomide; Therapeutic resistance

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Factores de Transcripción / Proteína p53 Supresora de Tumor / Resistencia a Antineoplásicos / Ubiquitina-Proteína Ligasas / Proliferación Celular / Proteínas de Motivos Tripartitos / Temozolomida / Glioma Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Biochem Biophys Res Commun Año: 2021 Tipo del documento: Article País de afiliación: China

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