Reference values for T and B lymphocyte subpopulations in Turkish children and adults
Turk J Med Sci
; 51(4): 1814-1824, 2021 08 30.
Article
en En
| MEDLINE
| ID: mdl-33754649
ABSTRACT
Background/aim:
Established reference values are critical for the interpretation of immunologic assessments. In particular, the proportion and absolute counts of T- and B- cell subpopulations are subject to change with age and ethnicity. We aimed to establish age- specific reference values for lymphocyte subsets using updated immunophenotyping panels. Materials andmethods:
We studied a total of 297 healthy Turkish subjects aged 0 to 50 years, stratified into major age brackets in a cluster factor of 10 per age-group. The predetermined age intervals contained randomly allocated participants enrolled over a period of 6 months, who were homogenously distributed by sex. We analyzed a complete blood count test and simultaneously with detailed immunophenotyping enumerated the percent and absolute cell counts of lymphocyte subsets.Results:
The percentage and absolute counts of lymphocyte subsets show a marked surge across the age-span. T helper, T cytotoxic, and the natural killer cell numbers were increasing from birth until 6 months, followed by a gradual decrease thereafter. B cell numbers were rising until 2 years, followed by a gradual decrease for the upcoming years, accompanied by a steady expansion of unclass-switched- and class-switched- B cells.Conclusion:
We provide updated extensive reference intervals for lymphocyte subpopulations in Turkish people.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Subgrupos de Linfocitos B
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Subgrupos de Linfocitos T
Límite:
Adolescent
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Adult
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Child
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Child, preschool
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Female
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Humans
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Infant
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Male
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Middle aged
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Newborn
País/Región como asunto:
Asia
Idioma:
En
Revista:
Turk J Med Sci
Año:
2021
Tipo del documento:
Article
País de afiliación:
Turquía