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Discovery of 6-substituted thieno[2,3-d]pyrimidine analogs as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis in folate receptor expressing human tumors.
Wallace-Povirk, Adrianne; Tong, Nian; Wong-Roushar, Jennifer; O'Connor, Carrie; Zhou, Xilin; Hou, Zhanjun; Bao, Xun; Garcia, Gloria E; Li, Jing; Kim, Seongho; Dann, Charles E; Matherly, Larry H; Gangjee, Aleem.
Afiliación
  • Wallace-Povirk A; Department of Oncology, Wayne State University School of Medicine, Detroit, MI 48201, United States.
  • Tong N; Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA 15282, United States.
  • Wong-Roushar J; Department of Chemistry, Indiana University, Bloomington, IN 47405, United States.
  • O'Connor C; Department of Oncology, Wayne State University School of Medicine, Detroit, MI 48201, United States.
  • Zhou X; Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA 15282, United States.
  • Hou Z; Department of Oncology, Wayne State University School of Medicine, Detroit, MI 48201, United States; Barbara Ann Karmanos Cancer Institute, Detroit, MI 48201, United States.
  • Bao X; Department of Oncology, Wayne State University School of Medicine, Detroit, MI 48201, United States.
  • Garcia GE; Department of Chemistry, Indiana University, Bloomington, IN 47405, United States.
  • Li J; Department of Oncology, Wayne State University School of Medicine, Detroit, MI 48201, United States; Barbara Ann Karmanos Cancer Institute, Detroit, MI 48201, United States.
  • Kim S; Department of Oncology, Wayne State University School of Medicine, Detroit, MI 48201, United States; Barbara Ann Karmanos Cancer Institute, Detroit, MI 48201, United States.
  • Dann CE; Department of Chemistry, Indiana University, Bloomington, IN 47405, United States. Electronic address: cedann@indiana.edu.
  • Matherly LH; Department of Oncology, Wayne State University School of Medicine, Detroit, MI 48201, United States; Barbara Ann Karmanos Cancer Institute, Detroit, MI 48201, United States. Electronic address: matherly@karmanos.org.
  • Gangjee A; Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA 15282, United States. Electronic address: gangjee@duq.edu.
Bioorg Med Chem ; 37: 116093, 2021 05 01.
Article en En | MEDLINE | ID: mdl-33773393
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Pirimidinas / Tiofenos / Inhibidores Enzimáticos / Fosforribosilaminoimidazolcarboxamida-Formiltransferasa / Fosforribosilglicinamida-Formiltransferasa / Antineoplásicos Límite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Pirimidinas / Tiofenos / Inhibidores Enzimáticos / Fosforribosilaminoimidazolcarboxamida-Formiltransferasa / Fosforribosilglicinamida-Formiltransferasa / Antineoplásicos Límite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos