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A STING antagonist modulating the interaction with STIM1 blocks ER-to-Golgi trafficking and inhibits lupus pathology.
Prabakaran, Thaneas; Troldborg, Anne; Kumpunya, Sarinya; Alee, Isara; Marinkovic, Emilija; Windross, Samuel J; Nandakumar, Ramya; Narita, Ryo; Zhang, Bao-Cun; Carstensen, Mikkel; Vejvisithsakul, Pichpisith; Marqvorsen, Mikkel H S; Iversen, Marie B; Holm, Christian K; Østergaard, Lars J; Pedersen, Finn Skou; Pisitkun, Trairak; Behrendt, Rayk; Pisitkun, Prapaporn; Paludan, Søren R.
Afiliación
  • Prabakaran T; Department of Biomedicine, Aarhus University, Aarhus DK-8000, Denmark.
  • Troldborg A; Department of Biomedicine, Aarhus University, Aarhus DK-8000, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus DK-8000, Denmark; Department of Rheumatology, Aarhus University Hospital, Aarhus N 8200, Denmark.
  • Kumpunya S; Center of Excellence in Systems Biology, Research Affairs, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Inter-Department Program of Biomedical Sciences, Faculty of Graduate, Chulalongkorn University, Bangkok, Thailand.
  • Alee I; Center of Excellence in Systems Biology, Research Affairs, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Inter-Department Program of Biomedical Sciences, Faculty of Graduate, Chulalongkorn University, Bangkok, Thailand.
  • Marinkovic E; Institute for Immunology, Faculty of Medicine, Technical University Dresden, Dresden, Germany.
  • Windross SJ; Department of Biomedicine, Aarhus University, Aarhus DK-8000, Denmark.
  • Nandakumar R; Department of Biomedicine, Aarhus University, Aarhus DK-8000, Denmark.
  • Narita R; Department of Biomedicine, Aarhus University, Aarhus DK-8000, Denmark.
  • Zhang BC; Department of Biomedicine, Aarhus University, Aarhus DK-8000, Denmark.
  • Carstensen M; Department of Biomedicine, Aarhus University, Aarhus DK-8000, Denmark.
  • Vejvisithsakul P; Department of Biomedicine, Aarhus University, Aarhus DK-8000, Denmark; Section for Translational Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
  • Marqvorsen MHS; Department of Biomedicine, Aarhus University, Aarhus DK-8000, Denmark.
  • Iversen MB; Department of Biomedicine, Aarhus University, Aarhus DK-8000, Denmark.
  • Holm CK; Department of Biomedicine, Aarhus University, Aarhus DK-8000, Denmark.
  • Østergaard LJ; Department of Clinical Medicine, Aarhus University, Aarhus DK-8000, Denmark; Department of Infectious Diseases, Aarhus University Hospital, Aarhus N 8200, Denmark.
  • Pedersen FS; Department of Molecular Biology and Genetics, Aarhus University, Aarhus DK-8000, Denmark.
  • Pisitkun T; Center of Excellence in Systems Biology, Research Affairs, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
  • Behrendt R; Institute for Immunology, Faculty of Medicine, Technical University Dresden, Dresden, Germany.
  • Pisitkun P; Section for Translational Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; Division of Allergy, Immunology, and Rheumatology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
  • Paludan SR; Department of Biomedicine, Aarhus University, Aarhus DK-8000, Denmark. Electronic address: srp@biomed.au.dk.
EBioMedicine ; 66: 103314, 2021 Apr.
Article en En | MEDLINE | ID: mdl-33813142
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Retículo Endoplásmico / Molécula de Interacción Estromal 1 / Aparato de Golgi / Lupus Eritematoso Sistémico / Proteínas de la Membrana / Proteínas de Neoplasias Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: EBioMedicine Año: 2021 Tipo del documento: Article País de afiliación: Dinamarca
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Retículo Endoplásmico / Molécula de Interacción Estromal 1 / Aparato de Golgi / Lupus Eritematoso Sistémico / Proteínas de la Membrana / Proteínas de Neoplasias Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: EBioMedicine Año: 2021 Tipo del documento: Article País de afiliación: Dinamarca