Calcium pectinate and hyaluronic acid modified lactoferrin nanoparticles loaded rhein with dual-targeting for ulcerative colitis treatment.

Luo, Ruifeng; Lin, Meisi; Fu, Chaomei; Zhang, Jinming; Chen, Qiyan; Zhang, Chen; Shi, Jinfeng; Pu, Xiulan; Dong, Linlin; Xu, Haiting; Ye, Naijing; Sun, Jiayi; Lin, Dasheng; Deng, Bin; McDowell, Arlene; Fu, Shu; Gao, Fei

Luo, Ruifeng; Lin, Meisi; Fu, Chaomei; Zhang, Jinming; Chen, Qiyan; Zhang, Chen; Shi, Jinfeng; Pu, Xiulan; Dong, Linlin; Xu, Haiting; Ye, Naijing; Sun, Jiayi; Lin, Dasheng; Deng, Bin; McDowell, Arlene; Fu, Shu; Gao, Fei.

Afiliación

Luo R; State Key Laboratory of Southwestern Chinese Medicine Resources, Pharmacy School, Chengdu University of Traditional Chinese Medicine, Chengdu, 611130, China.
Lin M; State Key Laboratory of Southwestern Chinese Medicine Resources, Pharmacy School, Chengdu University of Traditional Chinese Medicine, Chengdu, 611130, China; Affiliated Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, 610072, China; Sichuan Provincial Acupuncture School, Chengd
Fu C; State Key Laboratory of Southwestern Chinese Medicine Resources, Pharmacy School, Chengdu University of Traditional Chinese Medicine, Chengdu, 611130, China.
Zhang J; State Key Laboratory of Southwestern Chinese Medicine Resources, Pharmacy School, Chengdu University of Traditional Chinese Medicine, Chengdu, 611130, China.
Chen Q; State Key Laboratory of Southwestern Chinese Medicine Resources, Pharmacy School, Chengdu University of Traditional Chinese Medicine, Chengdu, 611130, China.
Zhang C; State Key Laboratory of Southwestern Chinese Medicine Resources, Pharmacy School, Chengdu University of Traditional Chinese Medicine, Chengdu, 611130, China.
Shi J; State Key Laboratory of Southwestern Chinese Medicine Resources, Pharmacy School, Chengdu University of Traditional Chinese Medicine, Chengdu, 611130, China.
Pu X; State Key Laboratory of Southwestern Chinese Medicine Resources, Pharmacy School, Chengdu University of Traditional Chinese Medicine, Chengdu, 611130, China.
Dong L; State Key Laboratory of Southwestern Chinese Medicine Resources, Pharmacy School, Chengdu University of Traditional Chinese Medicine, Chengdu, 611130, China.
Xu H; State Key Laboratory of Southwestern Chinese Medicine Resources, Pharmacy School, Chengdu University of Traditional Chinese Medicine, Chengdu, 611130, China.
Ye N; Affiliated Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, 610072, China.
Sun J; Innovative Institute of Chinese of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611130, China.
Lin D; Chengdu Huasun Technology Group Co. LTD, Chengdu, 611731, China.
Deng B; Chengdu Diao Pharmaceutical Group Co. LTD, Chengdu, 611731, China.
McDowell A; School of Pharmacy, University of Otago, Dunedin, 9054, New Zealand. Electronic address: arlene.mcdowell@otago.ac.nz.
Fu S; State Key Laboratory of Southwestern Chinese Medicine Resources, Pharmacy School, Chengdu University of Traditional Chinese Medicine, Chengdu, 611130, China. Electronic address: 61769335@qq.com.
Gao F; State Key Laboratory of Southwestern Chinese Medicine Resources, Pharmacy School, Chengdu University of Traditional Chinese Medicine, Chengdu, 611130, China. Electronic address: feigao207@yeah.net.

Carbohydr Polym ; 263: 117998, 2021 Jul 01.

Article en En | MEDLINE | ID: mdl-33858583

Asunto(s)

Antraquinonas/farmacología; Colitis Ulcerosa/tratamiento farmacológico; Inhibidores Enzimáticos/farmacología; Ácido Hialurónico/química; Lactoferrina/química; Nanopartículas/química; Pectinas/química; Animales; Antraquinonas/química; Transporte Biológico; Línea Celular; Colitis Ulcerosa/inducido químicamente; Colitis Ulcerosa/metabolismo; Colitis Ulcerosa/patología; Citocinas/metabolismo; Sulfato de Dextran/toxicidad; Modelos Animales de Enfermedad; Portadores de Fármacos/uso terapéutico; Liberación de Fármacos; Inhibidores Enzimáticos/química; Células Epiteliales/efectos de los fármacos; Células Epiteliales/metabolismo; Humanos; Receptores de Hialuranos/metabolismo; Macrófagos/efectos de los fármacos; Macrófagos/metabolismo; Ratones; FN-kappa B/antagonistas & inhibidores; Nanopartículas/uso terapéutico; Receptores de Superficie Celular/metabolismo; Proteínas de Uniones Estrechas/metabolismo; Distribución Tisular; Receptor Toll-Like 4/antagonistas & inhibidores

Palabras clave

Colonic mucous damage repair; Dual targeting; Inflammatory; Rhein; Ulcerative colitis

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Colitis Ulcerosa / Antraquinonas / Pectinas / Inhibidores Enzimáticos / Nanopartículas / Ácido Hialurónico / Lactoferrina Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Carbohydr Polym Año: 2021 Tipo del documento: Article País de afiliación: China

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