Identification of EMT signaling cross-talk and gene regulatory networks by single-cell RNA sequencing.

Deshmukh, Abhijeet P; Vasaikar, Suhas V; Tomczak, Katarzyna; Tripathi, Shubham; den Hollander, Petra; Arslan, Emre; Chakraborty, Priyanka; Soundararajan, Rama; Jolly, Mohit Kumar; Rai, Kunal; Levine, Herbert; Mani, Sendurai A

Deshmukh, Abhijeet P; Vasaikar, Suhas V; Tomczak, Katarzyna; Tripathi, Shubham; den Hollander, Petra; Arslan, Emre; Chakraborty, Priyanka; Soundararajan, Rama; Jolly, Mohit Kumar; Rai, Kunal; Levine, Herbert; Mani, Sendurai A.

Afiliación

Deshmukh AP; Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030.
Vasaikar SV; Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030.
Tomczak K; Department of Genomic Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030.
Tripathi S; Center for Theoretical Biological Physics, Northeastern University, Boston, MA 02115.
den Hollander P; Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030.
Arslan E; Department of Genomic Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030.
Chakraborty P; Centre for BioSystems Science and Engineering, Indian Institute of Science, 560012 Bangalore, India.
Soundararajan R; Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030.
Jolly MK; Centre for BioSystems Science and Engineering, Indian Institute of Science, 560012 Bangalore, India.
Rai K; Department of Genomic Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030; krai@mdanderson.org h.levine@northeastern.edu Smani@mdanderson.org.
Levine H; Center for Theoretical Biological Physics, Northeastern University, Boston, MA 02115; krai@mdanderson.org h.levine@northeastern.edu Smani@mdanderson.org.
Mani SA; Department of Physics, Northeastern University, Boston, MA 02115.

Proc Natl Acad Sci U S A ; 118(19)2021 05 11.

Article en En | MEDLINE | ID: mdl-33941680

Asunto(s)

Transición Epitelial-Mesenquimal/genética; Redes Reguladoras de Genes; RNA-Seq/métodos; Transducción de Señal/genética; Análisis de la Célula Individual/métodos; Línea Celular; Células Epiteliales/efectos de los fármacos; Células Epiteliales/metabolismo; Transición Epitelial-Mesenquimal/efectos de los fármacos; Perfilación de la Expresión Génica/métodos; Perfilación de la Expresión Génica/estadística & datos numéricos; Humanos; Estimación de Kaplan-Meier; MicroARNs/genética; Neoplasias/clasificación; Neoplasias/genética; Pronóstico; Modelos de Riesgos Proporcionales; Transducción de Señal/efectos de los fármacos; Factor de Crecimiento Transformador beta1/metabolismo; Factor de Crecimiento Transformador beta1/farmacología

Palabras clave

EMT; NOTCH; RACIPE; scRNA-seq; signaling cascade

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Transducción de Señal / Redes Reguladoras de Genes / Análisis de la Célula Individual / Transición Epitelial-Mesenquimal / RNA-Seq Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Humans Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2021 Tipo del documento: Article

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