Exercise training as a modulator of epigenetic events in prostate tumors.
Prostate Cancer Prostatic Dis
; 25(1): 119-122, 2022 03.
Article
en En
| MEDLINE
| ID: mdl-34007020
ABSTRACT
BACKGROUND:
Exercise is increasingly recognized as an effective strategy to improve cancer prevention and prognosis. Several biological mechanisms mediating these benefits have been proposed, but the role of epigenetics remains largely unknown. Since epigenetics is highly susceptible to lifestyle factors, we hypothesized that exercise could affect the epigenome landscape in cancer tissues.METHODS:
Rats implanted with AT1 prostate tumors were randomized to either control or exercise training. microRNA expression, DNA methylation and histone acetylation were analyzed in the tumor tissue.RESULTS:
MiR-27a-5p appeared to be differently expressed between sedentary and trained rats. Furthermore, exercise increased global DNA methylation and decreased DNA methyltransferases mRNA expression in the tumor tissue. Histone acetylation however remained unaltered.CONCLUSION:
Overall, exercise might reverse some of the cancer-related epigenetic alterations in the prostate tumor tissue.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Condicionamiento Físico Animal
/
Neoplasias de la Próstata
/
Histonas
Tipo de estudio:
Clinical_trials
/
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Prostate Cancer Prostatic Dis
Asunto de la revista:
ENDOCRINOLOGIA
/
NEOPLASIAS
/
UROLOGIA
Año:
2022
Tipo del documento:
Article
País de afiliación:
Francia