The value of new drugs for advanced prostate cancer.
Cancer
; 127(18): 3457-3465, 2021 09 15.
Article
en En
| MEDLINE
| ID: mdl-34062620
ABSTRACT
BACKGROUND:
The US Food and Drug Administration has recently approved a number of new cancer drugs. The clinical trials that serve as the basis for new cancer drug approvals may not reflect how the drugs will perform in routine practice and do not measure the impact of the drugs on spending. The authors sought to evaluate the real-world effectiveness and value of drugs recently approved for advanced prostate cancer.METHODS:
Using Surveillance, Epidemiology, and End Results-Medicare data, the authors identified fee-for-service Medicare beneficiaries aged 65 years or older who began treatment with a drug approved for metastatic castration-resistant prostate cancer in 2007-2009, when only 1 drug was approved for metastatic castration-resistant prostate cancer, and in 2014-2016, when 5 additional drugs were approved. They calculated life expectancy and lifetime medical costs (ie, Medicare reimbursements) for each group.RESULTS:
Between 2007-2009 and 2014-2016, life expectancy increased by 12.6 months. Lifetime medical costs increased by $87,000. The incremental cost per life-year gained was $83,000.CONCLUSION:
The release of 5 new drugs coincided with increases in survival rates and spending. This study's estimates indicate that the new drugs collectively were cost-effective.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias de la Próstata Resistentes a la Castración
/
Antineoplásicos
Límite:
Aged
/
Humans
/
Male
País/Región como asunto:
America do norte
Idioma:
En
Revista:
Cancer
Año:
2021
Tipo del documento:
Article
País de afiliación:
Georgia