SMYD3-PARP16 axis accelerates unfolded protein response and mediates neointima formation.
Acta Pharm Sin B
; 11(5): 1261-1273, 2021 May.
Article
en En
| MEDLINE
| ID: mdl-34094832
ATF6, activating transcription factor 6; BIP, immunoglobulin heavy-chain binding protein; ChIP-seq, chromatin immunoprecipitation coupled with deep sequencing; DAPI, 4',6-diamidino-2-phenylindole; ECM, extracellular matrix; EGCG, epigallocatechin-3-gallate; ER, endoplasmic reticulum; Endoplasmic reticulum; H3K4, histone H3 lysine 4; IACUC, Institutional Animal Care and Use Committee; IRE1, inositol-requiring enzyme 1; MMP, matrix metal proteinase; Neointimal hyperplasia; PARP, poly(ADP-ribose) polymerases; PARP16; PCNA, proliferating cell nuclear antigen; PDGF, platelet-derived growth factor; PERK, protein kinase R (PKR)-like ER kinase; SMCs, smooth muscle cells; SMYD3; SMYD3, SET and MYND domain containing 3; UPR, unfolded protein response; VCAM-1, vascular cell adhesion molecule-1; VSMCs, vascular smooth muscle cells; Vascular smooth muscle cell; XBP-1, X-box binding protein-1; p-PERK, phosphate-PKR-like ER kinase; p-eIF2α, phosphate-eukaryotic initiation factor 2α; siRNA, small interfering RNA
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Acta Pharm Sin B
Año:
2021
Tipo del documento:
Article
País de afiliación:
China