SMYD3-PARP16 axis accelerates unfolded protein response and mediates neointima formation.

Long, Fen; Yang, Di; Wang, Jinghua; Wang, Qing; Ni, Ting; Wei, Gang; Zhu, Yizhun; Liu, Xinhua

Long, Fen; Yang, Di; Wang, Jinghua; Wang, Qing; Ni, Ting; Wei, Gang; Zhu, Yizhun; Liu, Xinhua.

Afiliación

Long F; Pharmacophenomics Laboratory, Human Phenome Institute, Fudan University, Shanghai 201203, China.
Yang D; Pharmacophenomics Laboratory, Human Phenome Institute, Fudan University, Shanghai 201203, China.
Wang J; Pharmacophenomics Laboratory, Human Phenome Institute, Fudan University, Shanghai 201203, China.
Wang Q; Pharmacophenomics Laboratory, Human Phenome Institute, Fudan University, Shanghai 201203, China.
Ni T; State Key Laboratory of Genetic Engineering & MOE Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center of Genetics and Development, School of Life Sciences and Shanghai Cancer Center, Fudan University, Shanghai 200438, China.
Wei G; State Key Laboratory of Genetic Engineering & MOE Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center of Genetics and Development, School of Life Sciences and Shanghai Cancer Center, Fudan University, Shanghai 200438, China.
Zhu Y; State Key Laboratory of Quality Research in Chinese Medicine and School of Pharmacy, Macau University of Science and Technology, Macau, China.
Liu X; Pharmacophenomics Laboratory, Human Phenome Institute, Fudan University, Shanghai 201203, China.

Acta Pharm Sin B ; 11(5): 1261-1273, 2021 May.

Article en En | MEDLINE | ID: mdl-34094832

Palabras clave

ATF6, activating transcription factor 6; BIP, immunoglobulin heavy-chain binding protein; ChIP-seq, chromatin immunoprecipitation coupled with deep sequencing; DAPI, 4',6-diamidino-2-phenylindole; ECM, extracellular matrix; EGCG, epigallocatechin-3-gallate; ER, endoplasmic reticulum; Endoplasmic reticulum; H3K4, histone H3 lysine 4; IACUC, Institutional Animal Care and Use Committee; IRE1, inositol-requiring enzyme 1; MMP, matrix metal proteinase; Neointimal hyperplasia; PARP, poly(ADP-ribose) polymerases; PARP16; PCNA, proliferating cell nuclear antigen; PDGF, platelet-derived growth factor; PERK, protein kinase R (PKR)-like ER kinase; SMCs, smooth muscle cells; SMYD3; SMYD3, SET and MYND domain containing 3; UPR, unfolded protein response; VCAM-1, vascular cell adhesion molecule-1; VSMCs, vascular smooth muscle cells; Vascular smooth muscle cell; XBP-1, X-box binding protein-1; p-PERK, phosphate-PKR-like ER kinase; p-eIF2α, phosphate-eukaryotic initiation factor 2α; siRNA, small interfering RNA

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Acta Pharm Sin B Año: 2021 Tipo del documento: Article País de afiliación: China

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