Age- and airway disease related gene expression patterns of key SARS-CoV-2 entry factors in human nasal epithelia.
Virology
; 561: 65-68, 2021 09.
Article
en En
| MEDLINE
| ID: mdl-34157565
ABSTRACT
The global COVID-19 pandemic caused by SARS-CoV-2 predominantly affects the elderly. Differential expression of SARS-CoV-2 entry genes may underlie the variable susceptibility in different patient groups. Here, we examined the gene expression of key SARS-CoV-2 entry factors in mucosal biopsies to delineate the roles of age and existing chronic airway disease. A significant inverse correlation between ACE2 and age and a downregulation of NRP1 in patients with airway disease were noted. These results indicate that the interplay between various factors may influence susceptibility and the disease course.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Regulación de la Expresión Génica
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Interacciones Huésped-Patógeno
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SARS-CoV-2
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COVID-19
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Mucosa Nasal
Límite:
Adolescent
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Adult
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Aged
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Child
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Child, preschool
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Female
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Humans
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Infant
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Male
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Middle aged
Idioma:
En
Revista:
Virology
Año:
2021
Tipo del documento:
Article