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Controlling Coagulation in Blood with Red Light.
Müller, Patricia; Sahlbach, Marlen; Gasper, Simone; Mayer, Günter; Müller, Jens; Pötzsch, Bernd; Heckel, Alexander.
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  • Müller P; Goethe University Frankfurt, Institute for Organic Chemistry and Chemical Biology, Max-von-Laue Str. 9, 60438, Frankfurt am Main, Germany.
  • Sahlbach M; Goethe University Frankfurt, Institute for Organic Chemistry and Chemical Biology, Max-von-Laue Str. 9, 60438, Frankfurt am Main, Germany.
  • Gasper S; University Hospital Bonn, Institute of Experimental Hematology and Transfusion Medicine, Venusberg-Campus 1, 53105, Bonn, Germany.
  • Mayer G; University of Bonn, Life and Medical Sciences Institute, Center of Aptamer Research & Development, Gerhard-Domagk-Str. 1, 53121, Bonn, Germany.
  • Müller J; University Hospital Bonn, Institute of Experimental Hematology and Transfusion Medicine, Venusberg-Campus 1, 53105, Bonn, Germany.
  • Pötzsch B; University Hospital Bonn, Institute of Experimental Hematology and Transfusion Medicine, Venusberg-Campus 1, 53105, Bonn, Germany.
  • Heckel A; Goethe University Frankfurt, Institute for Organic Chemistry and Chemical Biology, Max-von-Laue Str. 9, 60438, Frankfurt am Main, Germany.
Angew Chem Int Ed Engl ; 60(41): 22441-22446, 2021 10 04.
Article en En | MEDLINE | ID: mdl-34293228
ABSTRACT
Precise control of blood clotting and rapid reversal of anticoagulation are essential in many clinical situations. We were successful in modifying a thrombin-binding aptamer with a red-light photocleavable linker derived from Cy7 by Cu-catalyzed Click chemistry. We were able to show that we can successfully deactivate the modified aptamer with red light (660 nm) even in human blood-restoring the blood's natural coagulation capability.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Coagulación Sanguínea / Carbocianinas / Benzotiazoles / Luz / Anticoagulantes Límite: Humans Idioma: En Revista: Angew Chem Int Ed Engl Año: 2021 Tipo del documento: Article País de afiliación: Alemania
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Coagulación Sanguínea / Carbocianinas / Benzotiazoles / Luz / Anticoagulantes Límite: Humans Idioma: En Revista: Angew Chem Int Ed Engl Año: 2021 Tipo del documento: Article País de afiliación: Alemania