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Wild-type GBA1 increases the α-synuclein tetramer-monomer ratio, reduces lipid-rich aggregates, and attenuates motor and cognitive deficits in mice.
Glajch, Kelly E; Moors, Tim E; Chen, Yi; Bechade, Pascal A; Nam, Alice Y; Rajsombath, Molly M; McCaffery, Thomas D; Dettmer, Ulf; Weihofen, Andreas; Hirst, Warren D; Selkoe, Dennis J; Nuber, Silke.
Afiliación
  • Glajch KE; Neurodegenerative Diseases Research Unit, Biogen, Cambridge, MA 02142.
  • Moors TE; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
  • Chen Y; Neurodegenerative Diseases Research Unit, Biogen, Cambridge, MA 02142.
  • Bechade PA; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
  • Nam AY; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
  • Rajsombath MM; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
  • McCaffery TD; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
  • Dettmer U; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
  • Weihofen A; Neurodegenerative Diseases Research Unit, Biogen, Cambridge, MA 02142.
  • Hirst WD; Neurodegenerative Diseases Research Unit, Biogen, Cambridge, MA 02142.
  • Selkoe DJ; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115 snuber@bwh.harvard.edu dselkoe@bwh.harvard.edu.
  • Nuber S; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115 snuber@bwh.harvard.edu dselkoe@bwh.harvard.edu.
Proc Natl Acad Sci U S A ; 118(31)2021 08 03.
Article en En | MEDLINE | ID: mdl-34326260
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Regulación Enzimológica de la Expresión Génica / Alfa-Sinucleína / Glucosilceramidasa Tipo de estudio: Risk_factors_studies Límite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2021 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Regulación Enzimológica de la Expresión Génica / Alfa-Sinucleína / Glucosilceramidasa Tipo de estudio: Risk_factors_studies Límite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2021 Tipo del documento: Article