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Preemptive Endoluminal Vacuum Therapy to Reduce Morbidity After Minimally Invasive Ivor Lewis Esophagectomy: Including a Novel Grading System for Postoperative Endoscopic Assessment of GI-Anastomoses.
Müller, Philip C; Morell, Bernhard; Vetter, Diana; Raptis, Dimitri A; Kapp, Joshua R; Gubler, Christoph; Gutschow, Christian A.
Afiliación
  • Müller PC; Department of Visceral and Transplant Surgery, University Hospital Zurich, Switzerland.
  • Morell B; Department Gastroenterology, University Hospital Zurich, Switzerland.
  • Vetter D; Department of Visceral and Transplant Surgery, University Hospital Zurich, Switzerland.
  • Raptis DA; Department of HPB Surgery and Liver Transplantation, Royal Free Hospital and University College London, London, United Kingdom.
  • Kapp JR; Department of Visceral and Transplant Surgery, University Hospital Zurich, Switzerland.
  • Gubler C; Department Gastroenterology, University Hospital Zurich, Switzerland.
  • Gutschow CA; Department of Visceral and Transplant Surgery, University Hospital Zurich, Switzerland.
Ann Surg ; 274(5): 751-757, 2021 11 01.
Article en En | MEDLINE | ID: mdl-34334639
OBJECTIVE: Preemptive endoluminal vacuum therapy (pEVT) is a novel concept to reduce postoperative morbidity and has the potential to disrupt current treatment paradigms for patients undergoing esophagectomy. SUMMARY OF BACKGROUND DATA: Endoluminal vacuum therapy is an accepted treatment for AL after esophagectomy. METHODS: Retrospective analysis of patients undergoing minimally invasive Ivor Lewis esophagectomy with pEVT between 11/2017 and 10/2020. The sponge was removed endoscopically after 4-6 days, and anastomosis and gastric conduit were assessed according to a novel endoscopic grading system. Further management was customized according to endoscopic appearance and clinical course. Endpoints were postoperative morbidity and AL rate, defined according to the Clavien-Dindo (CD) and International Esodata Study Group classifications. RESULTS: PEVT was performed in 67 consecutive patients, 57 (85%) were high-risk patients with an ASA score >2, WHO/ECOG score >1, age >65 years, or BMI >29 kg/m2. Thirty patients experienced textbook outcome, and overall minor (≤CD IIIa) and major (≥CD IIIb) morbidity was 40.3% and 14.9% respectively. 30-day-mortality was 0%. Forty-nine patients (73%) had uneventful anastomotic healing after pEVT without further endoscopic treatment. The remaining 18 patients (27%) underwent prolonged EVT with uneventful anastomotic healing in 13 patients (19%), contained AL in 4 patients (6%), and 1 uncontained leakage (1.5%) in a case with proximal gastric conduit necrosis, resulting in an overall AL rate of 7.5%. CONCLUSIONS: PEVT is an innovative and safe procedure with a promising potential to reduce postoperative morbidity after minimally invasive Ivor Lewis esophagectomy and may be particularly valuable in highly comorbid cases.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Complicaciones Posoperatorias / Neoplasias Esofágicas / Endoscopía del Sistema Digestivo / Esofagectomía / Procedimientos Quirúrgicos Mínimamente Invasivos / Procedimientos de Cirugía Plástica Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Ann Surg Año: 2021 Tipo del documento: Article País de afiliación: Suiza

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Complicaciones Posoperatorias / Neoplasias Esofágicas / Endoscopía del Sistema Digestivo / Esofagectomía / Procedimientos Quirúrgicos Mínimamente Invasivos / Procedimientos de Cirugía Plástica Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Ann Surg Año: 2021 Tipo del documento: Article País de afiliación: Suiza