Structural features of Cryptococcus neoformans bifunctional GAR/AIR synthetase may present novel antifungal drug targets.

Chua, Sheena M H; Wizrah, Maha S I; Luo, Zhenyao; Lim, Bryan Y J; Kappler, Ulrike; Kobe, Bostjan; Fraser, James A

Chua, Sheena M H; Wizrah, Maha S I; Luo, Zhenyao; Lim, Bryan Y J; Kappler, Ulrike; Kobe, Bostjan; Fraser, James A.

Afiliación

Chua SMH; Australian Infectious Diseases Research Centre, The University of Queensland, St Lucia, Queensland, Australia; School of Chemistry & Molecular Biosciences, The University of Queensland, St Lucia, Queensland, Australia.
Wizrah MSI; Australian Infectious Diseases Research Centre, The University of Queensland, St Lucia, Queensland, Australia; School of Chemistry & Molecular Biosciences, The University of Queensland, St Lucia, Queensland, Australia.
Luo Z; School of Chemistry & Molecular Biosciences, The University of Queensland, St Lucia, Queensland, Australia; Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland, Australia.
Lim BYJ; Australian Infectious Diseases Research Centre, The University of Queensland, St Lucia, Queensland, Australia; School of Chemistry & Molecular Biosciences, The University of Queensland, St Lucia, Queensland, Australia; Institute for Molecular Bioscience, The University of Queensland, St Lucia, Q
Kappler U; Australian Infectious Diseases Research Centre, The University of Queensland, St Lucia, Queensland, Australia; School of Chemistry & Molecular Biosciences, The University of Queensland, St Lucia, Queensland, Australia.
Kobe B; Australian Infectious Diseases Research Centre, The University of Queensland, St Lucia, Queensland, Australia; School of Chemistry & Molecular Biosciences, The University of Queensland, St Lucia, Queensland, Australia; Institute for Molecular Bioscience, The University of Queensland, St Lucia, Q
Fraser JA; Australian Infectious Diseases Research Centre, The University of Queensland, St Lucia, Queensland, Australia; School of Chemistry & Molecular Biosciences, The University of Queensland, St Lucia, Queensland, Australia. Electronic address: j.fraser1@uq.edu.au.

J Biol Chem ; 297(4): 101091, 2021 10.

Article en En | MEDLINE | ID: mdl-34416230

Asunto(s)

Antifúngicos/química; Ligasas de Carbono-Nitrógeno; Criptococosis; Cryptococcus neoformans; Sistemas de Liberación de Medicamentos; Inhibidores Enzimáticos/química; Proteínas Fúngicas; Animales; Antifúngicos/uso terapéutico; Ligasas de Carbono-Nitrógeno/antagonistas & inhibidores; Ligasas de Carbono-Nitrógeno/química; Ligasas de Carbono-Nitrógeno/genética; Criptococosis/tratamiento farmacológico; Criptococosis/enzimología; Criptococosis/genética; Cryptococcus neoformans/enzimología; Cryptococcus neoformans/genética; Cristalografía por Rayos X; Inhibidores Enzimáticos/uso terapéutico; Proteínas Fúngicas/antagonistas & inhibidores; Proteínas Fúngicas/química; Proteínas Fúngicas/genética; Humanos; Ratones; Dominios Proteicos

Palabras clave

Cryptococcus neoformans; X-ray crystallography; enzyme kinetics; fungi; microbial pathogenesis; molecular genetics; multifunctional enzyme; nucleoside/nucleotide metabolism; purine; purine de novo biosynthesis

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas Fúngicas / Sistemas de Liberación de Medicamentos / Ligasas de Carbono-Nitrógeno / Criptococosis / Cryptococcus neoformans / Inhibidores Enzimáticos / Antifúngicos Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: J Biol Chem Año: 2021 Tipo del documento: Article País de afiliación: Australia

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google