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Metabolomics and integrated network pharmacology analysis reveal Tricin as the active anti-cancer component of Weijing decoction by suppression of PRKCA and sphingolipid signaling.
Li, Jia-Xin; Li, Run-Ze; Sun, Ao; Zhou, Hua; Neher, Erwin; Yang, Jia-Shun; Huang, Ju-Min; Zhang, Yi-Zhong; Jiang, Ze-Bo; Liang, Tu-Liang; Ma, Lin-Rui; Wang, Jian; Wang, Xuan-Run; Fan, Xiao-Qing; Huang, Jie; Xie, Ying; Liu, Liang; Tang, Ling; Leung, Elaine Lai-Han; Yan, Pei-Yu.
Afiliación
  • Li JX; Faculty of Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau, China.
  • Li RZ; Zhuhai Hospital of Integrated Traditional Chinese and Western Medicine, Zhuhai, China; Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, Macau University of Science and Technology, Macau, China.
  • Sun A; Faculty of Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau, China.
  • Zhou H; Faculty of Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau, China.
  • Neher E; Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, Macau University of Science and Technology, Macau, China.
  • Yang JS; Department of Rehabilitation Medicine, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China.
  • Huang JM; Faculty of Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau, China.
  • Zhang YZ; Faculty of Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau, China.
  • Jiang ZB; Faculty of Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau, China.
  • Liang TL; Faculty of Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau, China.
  • Ma LR; Faculty of Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau, China.
  • Wang J; Faculty of Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau, China.
  • Wang XR; Faculty of Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau, China.
  • Fan XQ; Faculty of Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau, China.
  • Huang J; Faculty of Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau, China.
  • Xie Y; Faculty of Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau, China.
  • Liu L; Faculty of Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau, China.
  • Tang L; School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China; Guangdong Provincial Key Laboratory of Chinese Medicine Pharmaceutics, Guangzhou 510515, China; Guangdong Provincial Engineering Laboratory of Chinese Medicine Preparation Technology, Guangzhou 510515, Chin
  • Leung EL; Faculty of Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau, China; Zhuhai Hospital of Integrated Traditional Chinese and Western Medicine, Zhuhai, China; Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery
  • Yan PY; Faculty of Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau, China. Electronic address: pyyan@must.edu.mo.
Pharmacol Res ; 171: 105574, 2021 09.
Article en En | MEDLINE | ID: mdl-34419228
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Flavonoides / Carcinoma de Pulmón de Células no Pequeñas / Carcinoma Pulmonar de Lewis / Neoplasias Pulmonares / Antineoplásicos Fitogénicos Límite: Animals / Female / Humans Idioma: En Revista: Pharmacol Res Asunto de la revista: FARMACOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: China
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Flavonoides / Carcinoma de Pulmón de Células no Pequeñas / Carcinoma Pulmonar de Lewis / Neoplasias Pulmonares / Antineoplásicos Fitogénicos Límite: Animals / Female / Humans Idioma: En Revista: Pharmacol Res Asunto de la revista: FARMACOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: China