Drug-induced modulations of hepatic heme metabolism. Neurological consequences.
Ann N Y Acad Sci
; 514: 248-55, 1987.
Article
en En
| MEDLINE
| ID: mdl-3442388
ABSTRACT
Administration of the porphyrinogenic agent DDEP to PB-pretreated rats results in acute hepatic heme depletion, which is a characteristic of acute hepatic porphyria. Such acute heme depletion is associated with impaired hepatic tryptophan degradation and enhanced serotonergic tone in the CNS. We showed that intestinal motility in these rats is also significantly decreased, indicating that the serotonergic tone of the enteric nervous system may also be enhanced. In addition, the marked hepatic accumulation of glucogenic precursors, observed in parallel, indicates that the elevated tryptophan levels may also block hepatic glucogenesis. The clinical implications of these findings to acute heme-deficient states, such as the acute hepatic porphyrias, was discussed.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Pirimetamina
/
Encéfalo
/
Serotonina
/
Hemo
/
Hígado
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Ann N Y Acad Sci
Año:
1987
Tipo del documento:
Article