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A photosensitizer with conformational restriction for enhanced photodynamic therapy.
Huang, Haiqiao; Long, Saran; Huang, Daipeng; Du, Jianjun; Fan, Jiangli; Peng, Xiaojun.
Afiliación
  • Huang H; State Key Laboratory of Fine Chemicals, Dalian university of Technology, 2 Linggong Road, Dalian 116024, P. R. China. pengxj@dlut.edu.cn.
  • Long S; State Key Laboratory of Fine Chemicals, Dalian university of Technology, 2 Linggong Road, Dalian 116024, P. R. China. pengxj@dlut.edu.cn.
  • Huang D; Shenzhen Research Institute, Dalian University of Technology, Nanshan District, Shenzhen, 518057, P. R. China.
  • Du J; Ningbo Institute of Dalian University of Technology, 26 Yucai Road, Jiangbei District, Ningbo 315016, P. R. China.
  • Fan J; State Key Laboratory of Fine Chemicals, Dalian university of Technology, 2 Linggong Road, Dalian 116024, P. R. China. pengxj@dlut.edu.cn.
  • Peng X; State Key Laboratory of Fine Chemicals, Dalian university of Technology, 2 Linggong Road, Dalian 116024, P. R. China. pengxj@dlut.edu.cn.
Chem Commun (Camb) ; 57(72): 9100-9103, 2021 Sep 09.
Article en En | MEDLINE | ID: mdl-34498645
ABSTRACT
A rigid hemicyanine CSZ-J and a flexible molecule ESZ-J were synthesized. In particular, the conformationally restrained CSZ-J had higher fluorescence quantum yields, longer fluorescence lifetimes and higher triplet state quantum yields. CSZ-J could generate highly cytotoxic ROS simultaneously via type I and type II processes. This will contribute to the design and development of new photosensitizers in the future.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Fotoquimioterapia / Carbocianinas / Fármacos Fotosensibilizantes / Antineoplásicos Límite: Humans Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2021 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Fotoquimioterapia / Carbocianinas / Fármacos Fotosensibilizantes / Antineoplásicos Límite: Humans Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2021 Tipo del documento: Article