Efficacy and safety of ketogenic dietary theraphies in infancy. A single-center experience in 42 infants less than two years of age.
Seizure
; 92: 106-111, 2021 Nov.
Article
en En
| MEDLINE
| ID: mdl-34500220
ABSTRACT
PURPOSE:
Ketogenic dietary therapies (KDT) are high-fat and low-carbohydrate diets that may achieve seizure control and improve cognitive state. We describe our KDT experience in infants (children less than two years of age). RESEARCH METHODS & PROCEDURES We conducted a retrospective, descriptive and observational study of 42 infants treated with KDT between 2000-2018.RESULTS:
The types of KDT started were classic ketogenic diet ratio 31 (40), ratio 41 (1) and modified ketogenic diet with medium-chain triglycerides (1). Four patients switched to a modified Atkins diet. During follow-up, 79%, 57%, 38% and 17% of infants remained on KDT at 3, 6, 12 and 24 months, respectively. Seizure reduction ≥50% compared to baseline was achieved in 50%, 45%, 38% and 17% at 3, 6, 12 and 24 months, respectively. Seizure control was excellent (reduction >90%) in 33%, 31%, 26% and 12%, and seizure-free infants were 9, 9, 10 and 4, at different follow-up intervals, respectively. Sixty-three percent of infants with West syndrome were responders to KDT. Mean length of KDT was 390 days (16 days-4.9 years). Ineffectiveness was the reason for withdrawal in 50% of patients. Early adverse effects (during first month) occurred in 40% of infants. The most frequent early side effects were asymptomatic hypoglycemia and gastrointestinal disturbances. Late-onset side effects occurred in 55-14% of infants during therapy, and most frequent were hypercalciuria and dyslipidaemia.CONCLUSION:
KDT are useful and effective treatments in infancy. Side effects are frequent but mild and easy to manage.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Dieta Cetogénica
/
Epilepsia Refractaria
Tipo de estudio:
Observational_studies
Límite:
Child
/
Humans
/
Infant
Idioma:
En
Revista:
Seizure
Asunto de la revista:
NEUROLOGIA
Año:
2021
Tipo del documento:
Article