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BK Virus and Cytomegalovirus Coinfections in Kidney Transplantation and Their Impact on Allograft Loss.
Herrera, Sabina; Bernal-Maurandi, Javier; Cofan, Frederic; Ventura, Pedro; Marcos, Maria Angeles; Linares, Laura; Cuesta, Genoveva; Diekmann, Fritz; Moreno, Asunción; Bodro, Marta.
Afiliación
  • Herrera S; Infectious Diseases Department, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona and Hospital Clinic, 08036 Barcelona, Spain.
  • Bernal-Maurandi J; Infectious Diseases Department, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona and Hospital Clinic, 08036 Barcelona, Spain.
  • Cofan F; Facultad de Medicina, Universidad de Alcalá, Alcalá de Henares, 28805 Madrid, Spain.
  • Ventura P; Department of Nephrology and Renal Transplantation, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona and Hospital Clinic, 08036 Barcelona, Spain.
  • Marcos MA; Department of Nephrology and Renal Transplantation, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona and Hospital Clinic, 08036 Barcelona, Spain.
  • Linares L; Microbiology Department, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona and Hospital Clinic, 08036 Barcelona, Spain.
  • Cuesta G; Infectious Diseases Department, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona and Hospital Clinic, 08036 Barcelona, Spain.
  • Diekmann F; Microbiology Department, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona and Hospital Clinic, 08036 Barcelona, Spain.
  • Moreno A; Department of Nephrology and Renal Transplantation, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona and Hospital Clinic, 08036 Barcelona, Spain.
  • Bodro M; Infectious Diseases Department, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona and Hospital Clinic, 08036 Barcelona, Spain.
J Clin Med ; 10(17)2021 Aug 24.
Article en En | MEDLINE | ID: mdl-34501226
ABSTRACT
We aimed to ascertain the interaction and effects of combined reactivations of BK virus and cytomegalovirus on kidney graft function. All consecutive kidney transplant recipients (KTR) between 2003 and 2016 were included. Of 1976 patients who received a kidney transplant, 23 (1.2%) presented BKV-associated nephropathy (BKVAN). Factors independently associated with BKVAN were diabetes mellitus (odds ratios (OR) 3.895%, confidence intervals (CI) (1.4-10.5)), acute allograft rejection (OR 2.8 95%, CI (1.1-7.6)) and nephrostomy requirement (OR 4.195%, CI (1.3-13)). Cytomegalovirus infection was diagnosed in 19% of KTR patients. Recipients with BKVAN presented more frequently with cytomegalovirus (CMV) infection compared to patients without BKVAN (39% vs. 19%, p = 0.02). Acute allograft rejection (OR 2.95%, CI (1.4-2.4)) and nephrostomy requirement (OR 2.95%, CI (1.2-3)) were independently associated with CMV infection. Sixteen patients (69%) with BKVAN had graft dysfunction at one-year post-transplant and eight of them (35%) lost their graft. Patients presenting with BKVAN and graft loss presented more frequently a cytomegalovirus infection (OR 2.295%, CI (1.3-4.3)). In conclusion, we found a relation between CMV infection and graft loss in patients presenting BKVAN, suggesting that patients with CMV reactivation should be actively screened for BKV.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: J Clin Med Año: 2021 Tipo del documento: Article País de afiliación: España

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: J Clin Med Año: 2021 Tipo del documento: Article País de afiliación: España