Follicular Helper T (T<sub>FH</sub>) Cell Targeting by TLR8 Signaling For Improving HBsAg-Specific B Cell Response In Chronic Hepatitis B Patients.

Ayithan, Natarajan; Tang, Lydia; Tan, Susanna K; Chen, Diana; Wallin, Jeffrey J; Fletcher, Simon P; Kottilil, Shyam; Poonia, Bhawna

Follicular Helper T (T_FH) Cell Targeting by TLR8 Signaling For Improving HBsAg-Specific B Cell Response In Chronic Hepatitis B Patients.

Ayithan, Natarajan; Tang, Lydia; Tan, Susanna K; Chen, Diana; Wallin, Jeffrey J; Fletcher, Simon P; Kottilil, Shyam; Poonia, Bhawna.

Afiliación

Ayithan N; Division of Clinical Care and Research, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, United States.
Tang L; Division of Clinical Care and Research, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, United States.
Tan SK; Clinical Research, Gilead Sciences Inc., Foster City, CA, United States.
Chen D; Clinical Research, Gilead Sciences Inc., Foster City, CA, United States.
Wallin JJ; Clinical Research, Gilead Sciences Inc., Foster City, CA, United States.
Fletcher SP; Clinical Research, Gilead Sciences Inc., Foster City, CA, United States.
Kottilil S; Division of Clinical Care and Research, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, United States.
Poonia B; Division of Clinical Care and Research, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, United States.

Front Immunol ; 12: 735913, 2021.

Article en En | MEDLINE | ID: mdl-34512670

Asunto(s)

Antivirales/uso terapéutico; Linfocitos B/efectos de los fármacos; Antígenos de Superficie de la Hepatitis B/inmunología; Virus de la Hepatitis B/inmunología; Hepatitis B Crónica/tratamiento farmacológico; Hexanoles/uso terapéutico; Pirimidinas/uso terapéutico; Células T Auxiliares Foliculares/efectos de los fármacos; Receptor Toll-Like 8/agonistas; Linfocitos B/inmunología; Linfocitos B/metabolismo; Linfocitos B/virología; Ligando de CD40/metabolismo; Estudios de Casos y Controles; Células Cultivadas; Ensayo de Immunospot Ligado a Enzimas; Virus de la Hepatitis B/patogenicidad; Hepatitis B Crónica/inmunología; Hepatitis B Crónica/metabolismo; Hepatitis B Crónica/virología; Interacciones Huésped-Patógeno; Humanos; Proteína Coestimuladora de Linfocitos T Inducibles/metabolismo; Interleucinas/metabolismo; Proteínas Proto-Oncogénicas c-bcl-6/metabolismo; Transducción de Señal; Células T Auxiliares Foliculares/inmunología; Células T Auxiliares Foliculares/metabolismo; Células T Auxiliares Foliculares/virología; Receptor Toll-Like 8/metabolismo; Resultado del Tratamiento

Palabras clave

B cell; HBsAg-specific B cell response; activation induced marker (AIM); chronic hepatitis B; follicular helper T cell; inflammatory cytokine; selgantolimod (SLGN); toll-like receptor 8

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Antivirales / Pirimidinas / Linfocitos B / Virus de la Hepatitis B / Hepatitis B Crónica / Hexanoles / Receptor Toll-Like 8 / Células T Auxiliares Foliculares / Antígenos de Superficie de la Hepatitis B Tipo de estudio: Clinical_trials / Observational_studies / Prognostic_studies Límite: Humans Idioma: En Revista: Front Immunol Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos

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