Current and emerging mass spectrometry methods for the preclinical development of metal-based drugs: a critical appraisal.
Anal Bioanal Chem
; 414(1): 95-102, 2022 Jan.
Article
en En
| MEDLINE
| ID: mdl-34642780
ABSTRACT
This Trends article highlights the multiple ways in which the state-of-the-art molecular mass spectrometry can support the preclinical development of novel metal-based anticancer drugs. Examples from the recent literature-beyond routine characterization applications-are presented to illustrate what analytical and experimental design challenges are to be addressed to facilitate the translation of promising drug candidates to clinical practice.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Espectrometría de Masas
/
Evaluación Preclínica de Medicamentos
/
Metales
/
Antineoplásicos
Límite:
Humans
Idioma:
En
Revista:
Anal Bioanal Chem
Año:
2022
Tipo del documento:
Article
País de afiliación:
Polonia