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Tumor DNA-methylome derived epigenetic fingerprint identifies HPV-negative head and neck patients at risk for locoregional recurrence after postoperative radiochemotherapy.
Tawk, Bouchra; Wirkner, Ute; Schwager, Christian; Rein, Katrin; Zaoui, Karim; Federspil, Philippe A; Adeberg, Sebastian; Linge, Annett; Ganswindt, Ute; Hess, Julia; Unger, Kristian; Tinhofer, Ingeborg; Budach, Volker; Lohaus, Fabian; Krause, Mechthild; Guberina, Maja; Stuschke, Martin; Balermpas, Panagiotis; Rödel, Claus; Grosu, Anca L; Schäfer, Henning; Zips, Daniel; Combs, Stephanie E; Pigorsch, Steffi; Zitzelsberger, Horst; Baumeister, Philipp; Kirchner, Thomas; Bewerunge-Hudler, Melanie; Weichert, Wilko; Hess, Jochen; Herpel, Esther; Belka, Claus; Baumann, Michael; Debus, Jürgen; Abdollahi, Amir.
Afiliación
  • Tawk B; German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Wirkner U; German Cancer Consortium (DKTK), Core Center Heidelberg, Heidelberg, Germany.
  • Schwager C; Clinical Cooperation Unit Translational Radiation Oncology, National Center for Tumor Diseases (NCT), Heidelberg University Hospital (UKHD), Heidelberg, Germany.
  • Rein K; Division of Molecular and Translational Radiation Oncology, Department of Radiation Oncology, Heidelberg Faculty of Medicine (MFHD) and Heidelberg University Hospital (UKHD), Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg, Germany.
  • Zaoui K; Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Oncology (NCRO), Heidelberg University, Heidelberg, Germany.
  • Federspil PA; German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Adeberg S; German Cancer Consortium (DKTK), Core Center Heidelberg, Heidelberg, Germany.
  • Linge A; Clinical Cooperation Unit Translational Radiation Oncology, National Center for Tumor Diseases (NCT), Heidelberg University Hospital (UKHD), Heidelberg, Germany.
  • Ganswindt U; Division of Molecular and Translational Radiation Oncology, Department of Radiation Oncology, Heidelberg Faculty of Medicine (MFHD) and Heidelberg University Hospital (UKHD), Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg, Germany.
  • Hess J; Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Oncology (NCRO), Heidelberg University, Heidelberg, Germany.
  • Unger K; German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Tinhofer I; German Cancer Consortium (DKTK), Core Center Heidelberg, Heidelberg, Germany.
  • Budach V; Clinical Cooperation Unit Translational Radiation Oncology, National Center for Tumor Diseases (NCT), Heidelberg University Hospital (UKHD), Heidelberg, Germany.
  • Lohaus F; Division of Molecular and Translational Radiation Oncology, Department of Radiation Oncology, Heidelberg Faculty of Medicine (MFHD) and Heidelberg University Hospital (UKHD), Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg, Germany.
  • Krause M; Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Oncology (NCRO), Heidelberg University, Heidelberg, Germany.
  • Guberina M; German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Stuschke M; German Cancer Consortium (DKTK), Core Center Heidelberg, Heidelberg, Germany.
  • Balermpas P; Clinical Cooperation Unit Translational Radiation Oncology, National Center for Tumor Diseases (NCT), Heidelberg University Hospital (UKHD), Heidelberg, Germany.
  • Rödel C; Division of Molecular and Translational Radiation Oncology, Department of Radiation Oncology, Heidelberg Faculty of Medicine (MFHD) and Heidelberg University Hospital (UKHD), Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg, Germany.
  • Grosu AL; Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Oncology (NCRO), Heidelberg University, Heidelberg, Germany.
  • Schäfer H; Department of Otorhinolaryngology, Head and Neck Surgery, Heidelberg University Hospital, Heidelberg, Germany.
  • Zips D; Department of Otorhinolaryngology, Head and Neck Surgery, Heidelberg University Hospital, Heidelberg, Germany.
  • Combs SE; German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Pigorsch S; German Cancer Consortium (DKTK), Core Center Heidelberg, Heidelberg, Germany.
  • Zitzelsberger H; Department of Radiation Oncology, University Hospital Heidelberg, Heidelberg, Germany.
  • Baumeister P; Heidelberg Institute of Radiation Oncology (HIRO), Heidelberg, Germany.
  • Kirchner T; Clinical Cooperation Unit Translational Radiation Oncology, National Center for Tumor Diseases (NCT), Heidelberg University Hospital (UKHD), Heidelberg, Germany.
  • Bewerunge-Hudler M; German Cancer Consortium (DKTK), Partner Site Dresden, Dresden, Germany.
  • Weichert W; Department of Radiotherapy and Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
  • Hess J; OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
  • Herpel E; National Center for Tumor Diseases (NCT), Partner Site Dresden, Dresden, Germany.
  • Belka C; Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
  • Baumann M; Helmholtz Association/Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany.
  • Debus J; German Cancer Consortium (DKTK), Partner Site Munich, Munich, Germany.
  • Abdollahi A; Department of Radiation Oncology, Medical University of Innsbruck, Innsbruck, Austria.
Int J Cancer ; 150(4): 603-616, 2022 02 15.
Article en En | MEDLINE | ID: mdl-34648658
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: ADN de Neoplasias / Metilación de ADN / Quimioradioterapia / Carcinoma de Células Escamosas de Cabeza y Cuello / Neoplasias de Cabeza y Cuello / Recurrencia Local de Neoplasia Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Int J Cancer Año: 2022 Tipo del documento: Article País de afiliación: Alemania
Texto completo
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PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: ADN de Neoplasias / Metilación de ADN / Quimioradioterapia / Carcinoma de Células Escamosas de Cabeza y Cuello / Neoplasias de Cabeza y Cuello / Recurrencia Local de Neoplasia Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Int J Cancer Año: 2022 Tipo del documento: Article País de afiliación: Alemania