Recurrent deletion of the short arm of chromosome 3 in human renal cell carcinoma: shift of the c-raf 1 locus.
J Natl Cancer Inst
; 77(6): 1187-95, 1986 Dec.
Article
en En
| MEDLINE
| ID: mdl-3467112
ABSTRACT
A cytogenetic study performed on 6 human renal cell carcinomas after short-term culture on extracellular matrix with serum-free medium showed aneuploidy without structural changes in 2 tumors and a rearrangement of the short arm of chromosome 3 in 4 tumors, including deletions and a translocation involving the 3p14 and 3p21 bands. Chromosomal in situ hybridization with a c-raf 1 probe demonstrated that in 2 renal cancers with del3(p14 or 21) the cellular oncogene had shifted from 3p25 to 3p14 as a result of an interstitial deletion.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Cromosomas Humanos Par 3
/
Proto-Oncogenes
/
Carcinoma de Células Renales
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Deleción Cromosómica
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Neoplasias Renales
Límite:
Humans
Idioma:
En
Revista:
J Natl Cancer Inst
Año:
1986
Tipo del documento:
Article