High-throughput bioanalysis of sitagliptin in plasma using direct analysis in real time mass spectrometry and its application in the pharmacokinetic study thereof.

Liu, Yingze; Meng, Xiangjun; Zhang, Yuyao; Zhang, Linge; Shan, Yuqin; Gu, Jingkai; Sun, Dong

Liu, Yingze; Meng, Xiangjun; Zhang, Yuyao; Zhang, Linge; Shan, Yuqin; Gu, Jingkai; Sun, Dong.

Afiliación

Liu Y; School of Pharmaceutical Sciences, Jilin University, Changchun, P. R. China.
Meng X; Beijing Institute of Drug Metabolism, Beijing, P. R. China.
Zhang Y; Research Center for Drug Metabolism, School of Life Sciences, Jilin University, Changchun, P. R. China.
Zhang L; Research Center for Drug Metabolism, School of Life Sciences, Jilin University, Changchun, P. R. China.
Shan Y; Research Center for Drug Metabolism, School of Life Sciences, Jilin University, Changchun, P. R. China.
Gu J; Research Center for Drug Metabolism, School of Life Sciences, Jilin University, Changchun, P. R. China.
Sun D; Research Center for Drug Metabolism, School of Life Sciences, Jilin University, Changchun, P. R. China.

J Sep Sci ; 45(2): 631-637, 2022 Jan.

Article en En | MEDLINE | ID: mdl-34709732

Asunto(s)

Diabetes Mellitus Tipo 2; Fosfato de Sitagliptina; Animales; Cromatografía Líquida de Alta Presión/métodos; Diabetes Mellitus Tipo 2/tratamiento farmacológico; Plasma; Ratas; Reproducibilidad de los Resultados; Extracción en Fase Sólida; Espectrometría de Masas en Tándem/métodos

Palabras clave

absolute quantitative; pharmacokinetics; rapid bioanalysis; sitagliptin

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Diabetes Mellitus Tipo 2 / Fosfato de Sitagliptina Límite: Animals Idioma: En Revista: J Sep Sci Año: 2022 Tipo del documento: Article

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