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Nucleotide excision repair leaves a mark on chromatin: DNA damage detection in nucleosomes.
Apelt, Katja; Lans, Hannes; Schärer, Orlando D; Luijsterburg, Martijn S.
Afiliación
  • Apelt K; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.
  • Lans H; Department of Molecular Genetics, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands.
  • Schärer OD; Center for Genomic Integrity, Institute for Basic Science, Ulsan, Republic of Korea.
  • Luijsterburg MS; Department of Biological Sciences, Ulsan National Institute of Science and Technology, Ulsan, Republic of Korea.
Cell Mol Life Sci ; 78(24): 7925-7942, 2021 Dec.
Article en En | MEDLINE | ID: mdl-34731255
ABSTRACT
Global genome nucleotide excision repair (GG-NER) eliminates a broad spectrum of DNA lesions from genomic DNA. Genomic DNA is tightly wrapped around histones creating a barrier for DNA repair proteins to access DNA lesions buried in nucleosomal DNA. The DNA-damage sensors XPC and DDB2 recognize DNA lesions in nucleosomal DNA and initiate repair. The emerging view is that a tight interplay between XPC and DDB2 is regulated by post-translational modifications on the damage sensors themselves as well as on chromatin containing DNA lesions. The choreography between XPC and DDB2, their interconnection with post-translational modifications such as ubiquitylation, SUMOylation, methylation, poly(ADP-ribos)ylation, acetylation, and the functional links with chromatin remodelling activities regulate not only the initial recognition of DNA lesions in nucleosomes, but also the downstream recruitment and necessary displacement of GG-NER factors as repair progresses. In this review, we highlight how nucleotide excision repair leaves a mark on chromatin to enable DNA damage detection in nucleosomes.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Daño del ADN / Cromatina / Nucleosomas / Procesamiento Proteico-Postraduccional / Enzimas Reparadoras del ADN / Reparación del ADN Tipo de estudio: Diagnostic_studies Límite: Animals / Humans Idioma: En Revista: Cell Mol Life Sci Asunto de la revista: BIOLOGIA MOLECULAR Año: 2021 Tipo del documento: Article País de afiliación: Países Bajos

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Daño del ADN / Cromatina / Nucleosomas / Procesamiento Proteico-Postraduccional / Enzimas Reparadoras del ADN / Reparación del ADN Tipo de estudio: Diagnostic_studies Límite: Animals / Humans Idioma: En Revista: Cell Mol Life Sci Asunto de la revista: BIOLOGIA MOLECULAR Año: 2021 Tipo del documento: Article País de afiliación: Países Bajos