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DPP inhibition alters the CXCR3 axis and enhances NK and CD8+ T cell infiltration to improve anti-PD1 efficacy in murine models of pancreatic ductal adenocarcinoma.
Fitzgerald, Allison A; Wang, Shangzi; Agarwal, Veena; Marcisak, Emily F; Zuo, Annie; Jablonski, Sandra A; Loth, Melanie; Fertig, Elana J; MacDougall, John; Zhukovsky, Eugene; Trivedi, Shubhendu; Bhatia, Dimple; O'Neill, Vince; Weiner, Louis M.
Afiliación
  • Fitzgerald AA; Department of Oncology, Georgetown University Medical Center, Washington, DC, USA.
  • Wang S; Department of Oncology, Georgetown University Medical Center, Washington, DC, USA.
  • Agarwal V; Immune-oncology, BioXcel Therapeutics Inc, New Haven, Connecticut, USA.
  • Marcisak EF; McKusick-Nathans Institute of the Department of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
  • Zuo A; Department of Oncology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
  • Jablonski SA; Department of Oncology, Georgetown University Medical Center, Washington, DC, USA.
  • Loth M; Department of Oncology, Georgetown University Medical Center, Washington, DC, USA.
  • Fertig EJ; McKusick-Nathans Institute of the Department of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
  • MacDougall J; Department of Oncology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
  • Zhukovsky E; Department of Applied Mathematics and Statistics, Johns Hopkins University Whiting School of Engineering, Baltimore, Maryland, USA.
  • Trivedi S; Totus Medicines, Cambridge, Massachusetts, USA.
  • Bhatia D; BioXcel Therapeutics Inc, New Haven, Connecticut, USA.
  • O'Neill V; BioXcel Therapeutics Inc, New Haven, Connecticut, USA.
  • Weiner LM; BioXcel Therapeutics Inc, New Haven, Connecticut, USA.
J Immunother Cancer ; 9(11)2021 11.
Article en En | MEDLINE | ID: mdl-34737215
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Células Asesinas Naturales / Linfocitos T / Adenocarcinoma / Carcinoma Ductal Pancreático / Receptores CXCR3 / Inhibidores de la Dipeptidil-Peptidasa IV / Inmunoterapia Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: J Immunother Cancer Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Células Asesinas Naturales / Linfocitos T / Adenocarcinoma / Carcinoma Ductal Pancreático / Receptores CXCR3 / Inhibidores de la Dipeptidil-Peptidasa IV / Inmunoterapia Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: J Immunother Cancer Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos