Quantitative analysis of neuronal mitochondrial movement reveals patterns resulting from neurotoxicity of rotenone and 6-hydroxydopamine.

Simões, Rui F; Pino, Rute; Moreira-Soares, Maurício; Kovarova, Jaromira; Neuzil, Jiri; Travasso, Rui; Oliveira, Paulo J; Cunha-Oliveira, Teresa; Pereira, Francisco B

Simões, Rui F; Pino, Rute; Moreira-Soares, Maurício; Kovarova, Jaromira; Neuzil, Jiri; Travasso, Rui; Oliveira, Paulo J; Cunha-Oliveira, Teresa; Pereira, Francisco B.

Afiliación

Simões RF; CNC, Center for Neuroscience and Cell Biology, UC Biotech, Cantanhede, Portugal.
Pino R; CISUC, Department of Informatics Engineering, University of Coimbra, Coimbra, Portugal.
Moreira-Soares M; OCBE, Faculty of Medicine, University of Oslo, Oslo, Norway.
Kovarova J; Centre for Bioinformatics, Faculty of Mathematics and Natural Sciences, University of Oslo, Oslo, Norway.
Neuzil J; Institute of Biotechnology, Czech Academy of Sciences, Prague-West, Czech Republic.
Travasso R; Institute of Biotechnology, Czech Academy of Sciences, Prague-West, Czech Republic.
Oliveira PJ; School of Medical Science, Griffith University, Southport, Queensland, Australia.
Cunha-Oliveira T; CFisUC, Department of Physics, University of Coimbra, Coimbra, Portugal.
Pereira FB; CNC, Center for Neuroscience and Cell Biology, UC Biotech, Cantanhede, Portugal.

FASEB J ; 35(12): e22024, 2021 12.

Article en En | MEDLINE | ID: mdl-34751984

Asunto(s)

Mitocondrias/patología; Dinámicas Mitocondriales; Neuroblastoma/patología; Neuronas/patología; Oxidopamina/efectos adversos; Rotenona/efectos adversos; Adrenérgicos/efectos adversos; Diferenciación Celular; Humanos; Mitocondrias/efectos de los fármacos; Neuroblastoma/inducido químicamente; Neuronas/efectos de los fármacos; Desacopladores/efectos adversos

Palabras clave

exploratory data analysis; live cell imaging; mitochondria movement; neurotoxicants; principal component analysis; trajectory descriptors

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Rotenona / Oxidopamina / Dinámicas Mitocondriales / Mitocondrias / Neuroblastoma / Neuronas Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: FASEB J Asunto de la revista: BIOLOGIA / FISIOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Portugal

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