The associations between body fat distribution and bone mineral density in the Oxford Biobank: a cross sectional study.
Expert Rev Endocrinol Metab
; 17(1): 75-81, 2022 01.
Article
en En
| MEDLINE
| ID: mdl-34859739
ABSTRACT
BACKGROUND:
Body composition is associated with bone mineral density (BMD), but the precise associations between body fat distribution and BMD remain unclear. The regional adipose tissue depots have different metabolic profiles. We hypothesized that they would have independent associations with BMD. RESEARCH DESIGN ANDMETHODS:
We used data from 4,900 healthy individuals aged 30-50 years old from the Oxford Biobank to analyze associations between regional fat mass, lean mass and total BMD.RESULTS:
Total lean mass was strongly positively associated with BMD. An increase in total BMD was observed with increasing mass of all the fat depots, as measured either by anthropometry or DXA, when accounting for lean mass. However, on adjustment for both total fat mass and lean mass, fat depot specific associations emerged. Increased android and visceral adipose tissue mass in men, and increased visceral adipose tissue mass in women, were associated with lower BMD.CONCLUSIONS:
Fat distribution alters the association between adiposity and BMD.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Densidad Ósea
/
Bancos de Muestras Biológicas
Tipo de estudio:
Observational_studies
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Prevalence_studies
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Risk_factors_studies
Límite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Expert Rev Endocrinol Metab
Año:
2022
Tipo del documento:
Article
País de afiliación:
Reino Unido