Selective EZH2 inhibitor zld1039 alleviates inflammation in cisplatin-induced acute kidney injury partially by enhancing RKIP and suppressing NF-&#954;B p65 pathway.

Wen, Li; Tao, Shao-Hua; Guo, Fan; Li, Ling-Zhi; Yang, Hong-Liu; Liang, Yan; Zhang, Li-Dan; Ma, Liang; Fu, Ping

Selective EZH2 inhibitor zld1039 alleviates inflammation in cisplatin-induced acute kidney injury partially by enhancing RKIP and suppressing NF-κB p65 pathway.

Wen, Li; Tao, Shao-Hua; Guo, Fan; Li, Ling-Zhi; Yang, Hong-Liu; Liang, Yan; Zhang, Li-Dan; Ma, Liang; Fu, Ping.

Afiliación

Wen L; Kidney Research Institute, National Clinical Research Center for Geriatrics and Division of Nephrology, West China Hospital of Sichuan University, Chengdu, 610041, China.
Tao SH; Kidney Research Institute, National Clinical Research Center for Geriatrics and Division of Nephrology, West China Hospital of Sichuan University, Chengdu, 610041, China.
Guo F; Kidney Research Institute, National Clinical Research Center for Geriatrics and Division of Nephrology, West China Hospital of Sichuan University, Chengdu, 610041, China.
Li LZ; Kidney Research Institute, National Clinical Research Center for Geriatrics and Division of Nephrology, West China Hospital of Sichuan University, Chengdu, 610041, China.
Yang HL; Kidney Research Institute, National Clinical Research Center for Geriatrics and Division of Nephrology, West China Hospital of Sichuan University, Chengdu, 610041, China.
Liang Y; Research Core Facility of West China Hospital, Chengdu, 610041, China.
Zhang LD; Laboratory of Anesthesia & Critical Care Medicine, Translational Neuroscience Center, West China Hospital of Sichuan University, Chengdu, 610041, China. zhanglidan0510@wchscu.cn.
Ma L; Kidney Research Institute, National Clinical Research Center for Geriatrics and Division of Nephrology, West China Hospital of Sichuan University, Chengdu, 610041, China. liang_m@scu.edu.cn.
Fu P; Kidney Research Institute, National Clinical Research Center for Geriatrics and Division of Nephrology, West China Hospital of Sichuan University, Chengdu, 610041, China.

Acta Pharmacol Sin ; 43(8): 2067-2080, 2022 Aug.

Article en En | MEDLINE | ID: mdl-34937916

Asunto(s)

Lesión Renal Aguda; Proteína Potenciadora del Homólogo Zeste 2; Inhibidores Enzimáticos; Proteínas de Unión a Fosfatidiletanolamina; Factor de Transcripción ReIA; Lesión Renal Aguda/inducido químicamente; Lesión Renal Aguda/tratamiento farmacológico; Lesión Renal Aguda/metabolismo; Animales; Antiinflamatorios/farmacología; Benzamidas/farmacología; Cisplatino/efectos adversos; Proteína Potenciadora del Homólogo Zeste 2/antagonistas & inhibidores; Inhibidores Enzimáticos/farmacología; Histonas/metabolismo; Inflamación; Ratones; FN-kappa B/metabolismo; Proteínas de Unión a Fosfatidiletanolamina/metabolismo; Quinolonas/farmacología; Factor de Transcripción ReIA/metabolismo

Palabras clave

NF-κB p65; Raf kinase inhibitor protein; acute kidney injury; enhancer of zeste homolog 2; inflammation; zld1039

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas de Unión a Fosfatidiletanolamina / Inhibidores Enzimáticos / Factor de Transcripción ReIA / Lesión Renal Aguda / Proteína Potenciadora del Homólogo Zeste 2 Límite: Animals Idioma: En Revista: Acta Pharmacol Sin Asunto de la revista: FARMACOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: China

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