[Research advances of occludin in vascular endothelial injury].
Sheng Li Xue Bao
; 73(6): 931-939, 2021 Dec 25.
Article
en Zh
| MEDLINE
| ID: mdl-34961868
ABSTRACT
Endothelial tight junctions (TJs) serve as an important barrier in vascular endothelial structure and maintain vascular function homeostasis. Occludin, the most representative tight junction protein, is involved in sealing cell connections and maintaining the integrity and permeability of vascular endothelium. Recent studies have shown that alterations in the expression, distribution, and structure of endothelial TJs may lead to many related vascular diseases and pathologies (such as stroke, atherosclerosis, and pulmonary hypertension etc.). Here, we reviewed the research advances on the relationship between occludin and vascular endothelial injury, including the biological information of occludin, the signal pathways that occludin exerts the protective effect of vascular endothelium, and the relationship between occludin and vascular endothelial injury-related diseases.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Endotelio Vascular
/
Uniones Estrechas
Idioma:
Zh
Revista:
Sheng Li Xue Bao
Año:
2021
Tipo del documento:
Article
País de afiliación:
China